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Article | 17-February-2021

The Xg blood group system: no longer forgotten

Erythrocyte Expression of the Xga and CD99 Antigens Since the previous review by Johnson in 2011,1 much of the work on the Xg blood group system has centered on identifying the genetic determinants of Xga and CD99 status. Strikingly, for a decade, the Xg system remained one of only two blood group systems for which the polymorphic blood group could not be genetically determined2—this scenario occurred despite the fact that the gene encoding Xga, XG (formerly PBDX), has been known since 1994.3

Y.Q. Lee, J.R. Storry, M.L. Olsson

Immunohematology, Volume 36 , ISSUE 1, 4–6

Review | 01-December-2019

XG: the forgotten blood group system

The XG blood group system is best known for its contributions to the fields of genetics and chromosome mapping. This system comprises two antigens, Xga and CD99, that are not antithetical but that demonstrate a unique phenotypic relationship. XG is located on the tip of the short arm of the X chromosome with exons 1 to 3 present in the pseudoautosomal region of the X (and Y) chromosome(s) and exons 4 to 10 located only on the X chromosome. Xga demonstrates a clear X-linked pattern of

Nanette C. Johnson

Immunohematology, Volume 27 , ISSUE 2, 68–71

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