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original-report | 30-September-2021

A unique approach to screen for blood donors lacking high-prevalence antigen Inb of the Indian blood group system

The Indian blood group system comprises six antigens, of which Ina (IN1) occurs in low prevalence among the people of Indian origin.1 Its antithetical antigen, Inb (IN2), and four other antigens―namely, INFI (IN3), INJA (IN4), INRA (IN5), and INSL (IN6)―are high-prevalence antigens (HPAs).2–5 Whereas most patients lacking these HPAs were found among people with ancestry in the Indian subcontinent, individuals lacking the INFI (IN3) antigen were found among Moroccans.3 A transfusion recipient

S.R. Joshi, S.B. Senjaliya, H.D. Maru, P.D. Kshirsagar, S.S. Kulkarni, P. Shrivastava

Immunohematology, Volume 37 , ISSUE 3, 126–130

Report | 11-March-2020

The Indian blood group system

The Indian blood group system (ISBT: IN/023) consists of two antithetical antigens: Ina (IN1), which is present in approximately 10 percent of some Arab populations and in 3 percent of Bombay Indians, and its allelic antigen Inb (IN2), an antigen of high incidence in all populations. In 2007, two new high-incidence antigens were identified as belonging to the IN blood group system, namely IN3 (INFI) and IN4 (INJA). The antigens in this system are located on CD44, a single-pass membrane

Qun Xu

Immunohematology, Volume 27 , ISSUE 3, 89–93

Article | 17-February-2021

A resource-conserving serologic and high-throughput molecular approach to screen for blood donors with an IN:−5 phenotype

blood group system comprises six antigens thus far, of which Ina is a low-prevalence antigen and Inb is an HPA, which together are an antithetical pair. Additionally, four other HPAs have been recognized, some of which were found to be clinically significant as to illicit immune response and to cause hemolytic transfusion reaction.8,12 Although an antibody to a low-prevalence antigen in a transfusion recipient may not pose a problem in finding units of antigen-negative blood for transfusion, an

S.R. Joshi, S.B. Senjaliya, K. Srivastava, W.A. Flegel

Immunohematology, Volume 36 , ISSUE 4, 129–132

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