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Research paper | 04-August-2017

High-dose 1,25-dihydroxyvitamin D supplementation elongates the lifespan of Huntington’s disease transgenic mice

a transgenic mouse model of Huntington’s disease. Methods: Our study was performed on N171-82Q Huntington’s disease transgenic mice in age- and gender-matched groups. We collected data on the motor state and survival of the mice. Results: The results demonstrate that though vitamin D3 had no effect on the motor performance of transgenic mice, but significantly increased the lifespan of transgenic animals (Kaplan-Meier survival curves: vehicle-supplemented group

Máté` Fort Molnár, Rita Török, Evelin Sümegi, László Vécsei, Péter Klivényi, Levente Szalárdy1

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 176–181

research-article | 30-November-2020

Cultivation of Caenorhabditis elegans on new cheap monoxenic media without peptone

of P0s). Then, the global average was determined by averaging the per batch average brood sizes. Note, the standard errors (SE) for each data set is the SE among P0 batches and not the SE across individual P0s. In addition, a batch smooths out the variation among individuals. Thus, among the batch SE is expected to be smaller than among individual SEs. Brood size comparisons were analyzed with one-way ANOVA and then Dunnett’s post-hoc test. Lifespan assay Ten L1 worms (P0) that were growing on

Tho Son Le, T. T. Hang Nguyen, Bui Thi Mai Huong, H. Gam Nguyen, B. Hong Ha, Van Sang Nguyen, Minh Hung Nguyen, Huy-Hoang Nguyen, John Wang

Journal of Nematology, Volume 53 , 1–23

Research paper | 10-October-2018

Effects of PINK1 mutation on synapses and behavior in the brain of Drosophila melanogaster

Mutations in the PINK1 gene are responsible for typical symptoms of Parkinson’s disease. Using Drosophila melanogaster mutant PINK1B9 and after PINK1 silencing with RNAi using transgenic lines, we observed defects in synapses and behavior. The lack or reduced expression of PINK1 prolonged sleep during the day (nap) and decreased the total locomotor activity during 24 h, in addition to a decrease in climbing ability and a reduced lifespan. In the brain, PINK1 mutants had a lower level of

Bartosz Doktór, Milena Damulewicz, Wojciech Krzeptowski, Barbara Bednarczyk, Elżbieta Pyza

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 231–241

research-article | 18-December-2020

Usefulness of high-frequency ultrasound to assess the healing progress of shin ulcers

Introduction Chronic shin ulcer is a chronic wound with complete skin loss which does not heal within 6–8 weeks or its surface does not decrease to a significant extent (by 20–40%) within 2–4 weeks. The prevalence of shin ulcers increases with age; they are found in 0.6–3% of patients aged over 60 and in 5% of patients aged over 80(1). As the average lifespan becomes longer, the number of chronic shin ulcers is rising, which is slowly becoming a societal problem. The most common causes of

Agnieszka Krauze, Witold Woźniak, Robert Krzysztof Mlosek

Journal of Ultrasonography, Volume 20 , ISSUE 83, 254–260

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