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Article | 16-November-2020

A method to detect McLeod phenotype red blood cells

It is important to identify the McLeod phenotype in order to differentiate the McLeod syndrome from other causes of acanthocytosis, e.g., chorea acanthocytosis. A proportion of males with the McLeod phenotype have X-linked chronic granulomatous disease. Because anti-Kx + -Km, which is needed for identification, is not readily available, detection of the McLeod phenotype relies on observed weakening of Kell antigens on the individual’s red blood cells (RBCs). Identification of McLeod

Ragnhild Øyen, Marion E. Reid, Pablo Rubinstein, Harold Ralph

Immunohematology, Volume 12 , ISSUE 4, 160–163

original-report | 25-June-2021

Effect of cryopreservation on a rare McLeod donor red blood cell concentrate

associated with membrane alterations have on deglycerolized RBC component quality, investigations to evaluate the downstream implications to patient care and cell banking practices would be useful. An example of a rare RBC phenotype that should be cryogenically banked is the McLeod phenotype. This phenotype results from the absence of the Kx protein on the RBC membrane due to various missense and small to major nucleotide deletions of the XK gene.2,3 This information is important because Kx, a 10-pass

T.R. Turner, G. Clarke, G.A. Denomme, R. Skeate, J.P. Acker

Immunohematology, Volume 37 , ISSUE 2, 78–83

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