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Article | 17-February-2021

An update on the RAPH blood group system

New RAPH Alleles Since publication of the original review in 2014,1 no new alleles have been identified that alter or eliminate MER2 expression. The CD151 c.494G>A allele identified in 20122 was assigned RAPH*-01.03 (Table 1). A recent study identified an individual homozygous for a splice defect at CD151 c.351+2T>C; this finding resulted in skipping exon 5 and was associated with lack of CD151 expression in the skin of the patient with Kindler syndrome–like epidermolysis bullosa and a history

M.A. Keller

Immunohematology, Volume 36 , ISSUE 2, 58–59

Review | 29-October-2019

Raph blood group system

This review describes the current state of knowledge of the Raph blood group system, which consists of a single antigen, MER2. MER2 was initially classified as a high-incidence antigen in the 901 series of blood groups, formerly known as 901011, but was reclassified as an antigen in the Raph blood group system in 2004. There have been six reports of human alloantibodies to MER2. Three of the subjects were found to have a stop codon in the CD151 gene, which encodes a member of the tetraspanin

Michele Hayes

Immunohematology, Volume 30 , ISSUE 1, 6–10

Review | 16-October-2019

Clinical significance of antibodies to antigens in the Raph, John Milton Hagen, I, Globoside, Gill, Rh-associated glycoprotein, FORS, JR, LAN, Vel, CD59, and Augustine blood group systems

This article reviews information on the clinical significance of antibodies to antigens in the Raph, John Milton Hagen, I, Globoside, Gill, Rh-associated glycoprotein, FORS, JR, LAN, Vel, CD59, and Augustine blood group systems. Antibodies to many of the antigens in these groups are rarely encountered because of the high prevalence of the associated antigens in most populations. For many of these antibodies, the clinical significance—that is, the potential to cause reduced survival of

Mostafa Moghaddam, Amir Ali Naghi

Immunohematology, Volume 34 , ISSUE 3, 85–90

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