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  • Immunohematology


Article | 16-October-2019

Clinical and laboratory profile of anti-M

The MNS blood group system was identified by Landsteiner and Levine in 1927.1 Many antibodies in this system may be naturally occurring. The most common of these is anti-M, first described by Wolff and Johnson in 1933.2 The MNS blood group system consists of 49 antigens, of which two allelic pairs (M/N and S/s) are polymorphic in most populations.3 M and N are located on glycophorin A glycoprotein. Glycophorin A is expressed on the surface of mature as well as developing erythrocytes.4 Makroo

D. Basu, S. Basu, M. Reddy, K. Gupta, M. Chandy

Immunohematology, Volume 33 , ISSUE 4, 165–169

Article | 16-February-2021

Acidification of plasma for detection of pH-dependent antibodies

carboxyl group charges of these sialic acids results in a negatively charged red blood cell (RBC) membrane.4 The pH dependency or enhancement of some antibodies with M specificity may be due to the charged carboxyl groups present on the glycophorin A that carry the M antigen.5 The first naturally occurring pH-dependent anti-M was discovered in 1964 when a saline agglutinin was present in a donor’s acid citrate dextrose plasma that was not demonstrable in the serum from the same donation. After

K.L. Bowman, B.C. Dunlap, L.M. Hawthorne, K.L. Billingsley

Immunohematology, Volume 35 , ISSUE 3, 116–118

Case report | 16-March-2020

Nonhemolytic passenger lymphocyte syndrome: donor-derived anti-M in an M+ recipient of a multiorgan transplant

serologic incompatibility was not associated with clinical evidence of hemolysis. This report describes a case of passenger lymphocyte syndrome in an M+ recipient who developed anti-M after receiving a multiorgan transplant from an M– cadaver donor. Although the temporal events and serologic findings were consistent with a diagnosis of PLS, there was no evidence of in vivo hemolysis associated with the identification of a newly formed anti-M. This report includes a literature review of other case

Addisalem T. Makuria, Albert Langeberg, Thomas M. Fishbein, S. Gerald Sandler

Immunohematology, Volume 25 , ISSUE 1, 20–23

Article | 29-December-2020

Assessing the clinical significance of anti-Cra and anti-M in a chronically transfused sickle cell patient

An alloantibody to a high-incidence antigen, asso­ciated with multiple other alloantibodies, made it impossible to supply antigen-negative red blood cells (RBCs) for a chronically transfused sickle cell anemia patient. Anti-Cra, -E, -K, -S, -Fya, -Fyb, as well as anti-M reactive at 37°C and in the antiglobulin phase of testing, were identified in the patient’s serum. An extensive search of rare donor files at the American Red Cross and at the American As­sociation of Blood

Mary B. Leatherbarrow, Sandra S. Ellisor, Patricia A. Collins, Deborah K. Douglas, Robert J. Eckrich, Susan S. Esty, Michael L. Baldwin, Paul M. Ness

Immunohematology, Volume 4 , ISSUE 4, 71–74

Case report | 17-November-2020

Case report: a pregnant woman with immune thrombocytopenic purpura and unusual red cell antibodies

Maternal immune thrombocytopenic purpura (ITP) may lead to fetal platelet destruction. This process is mediated by IgG platelet autoantibodies that cross the placenta. In this case, not only were platelet autoantibodies present, but red cell alloantibodies anti-E, anti-M, and anti-He were also present. Anti-E, present as an IgG antibody, crossed the placenta, but did not cause clinical problems in the E+ newborn, other than possible hyperbilirubinemia that was treated by phototherapy.

Carmela R. Nanton, Sharon M. Martin, Lloyd O. Cook, Patricia J. Larison

Immunohematology, Volume 11 , ISSUE 4, 153–155

Article | 10-November-2020

Detection of tube agglutination 37°C-only antibodies by solid-phase red cell adherence

antibodies reacted by SP, including three anti-c, two anti-D, two anti-E, one anti-N, and one anti-M. The anti-M reacted with indicator red cells that lacked the red cell antigen and failed to react with IgG-coated indicator red cells whose anti-IgG component had been neutralized, indicating the antibody contained an IgG component. Two anti-D and one anti-c continued to react in an SP test using neutralized anti-IgG antigen-positive indicator red cells, i.e., indica­tor binding independent of

Susan Rolih, Fern Fisher, Dolores Fiqueroa, Gwenn Lindsay

Immunohematology, Volume 12 , ISSUE 1, 27–29

Article | 14-October-2020

Antibodies detected in samples from 21,730 pregnant women

clinically significant antibodies was 2.4 percent. The majority belonged to the Rh system, followed by anti-M, -Fya , -S, -Jka , and -Jkb . Among antibodies of no clinical significance, the most frequent were antiH, -Lea , and -P1.

Snezana Jovanovic-Srzentic, Milan Djokic, Nenad Tijanic, Radmila Djordjevic, Nada Rizvan, Darko Plecas, Dejan Filimonovic

Immunohematology, Volume 19 , ISSUE 3, 89–92

Report | 01-December-2019

Prevalence of clinically significant red blood cell alloantibodies in pregnant women at a large tertiary-care facility

(3.0%) had one or more unexpected RBC antibodies. Of these 264 women, 107 (40.5%), or 1.2 percent overall, had an alloantibody known to cause HDFN, with a total of 15 different alloantibodies identified. The most common alloantibody found was anti-E (n = 33), followed by anti-M (n = 26) and anti-D (n = 20). In pregnancies of D– women, the most common clinically significant antibodies found were anti-D (n = 20), anti-C (n = 11), and anti-E (n = 2). In pregnancies of D+ women, the most common

Heather M. Smith, Rosetta S. Shirey, Sandra K. Thoman, Jay B. Jackson

Immunohematology, Volume 29 , ISSUE 4, 127–130

Case report | 01-December-2019

A case of masquerading alloantibodies:  the value of a multitechnique approach

) revealed the presence of four alloantibodies: anti-M and anti-E reacting at immediate spin, 37°C, and IAT plus anti-Fya and anti-Jkb reacting at IAT.

Paula M.S. Wennersten, Laurie J. Sutor

Immunohematology, Volume 30 , ISSUE 3, 117–120

Article | 09-November-2020

The gel test: sensitivity and specificity for unexpected antibodies to blood group antigens

of these (cold auto, anti-M, -Le, etc.) were considered harmless with respect to transfusion management. GEL–LISS+ tests included seven samples containing potentially significant antibodies (assumed from specificity): anti-K(4), -Jka, -Fyb, and -S. Two potentially significant antibodies (antiC and -D) were GEL+LISS–. Sensitivity and specificity for potentially significant antibodies were 92% and 96% for GEL, and 98% and 90% for LISS, respectively. The seven GEL–LISS+ samples

W. John Judd, E. Ann Steiner, Pamela C. Knaf

Immunohematology, Volume 13 , ISSUE 4, 132–135

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