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research-paper | 12-August-2019

Short-term exposure to high-intensity sound induces hearing loss and apoptosis in guinea pigs

following the exposure (Fernandez et al., 2015). Cochlear changes have become a primary focus in the study of sound-induced hearing problems (Liberman et al., 2015). Changes of inner hair cells (IHCs) and outer hair cells (OHCs) are the most significant effect in sound-induced hearing loss due to various causes, such as aging and noise (Han et al., 2013; Sergeyenko et al., 2013; Heeringa and van Dijk, 2014). Studies have shown that after noise exposure, necrosis and apoptosis occurred simultaneously in

Yanqing Liu, Hui Wang, Ziquan Liu, Yanjun Gu, Limin Xin, Jinyang Liu, Haojun Fan

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 155–168

original-paper | 04-June-2020

N-acetylcysteine (NAC) Attenuating Apoptosis and Autophagy in RAW264.7 Cells in Response to Incubation with Mycolic Acid from Bovine Mycobacterium tuberculosis Complex

free radicals, which increases the toxicity to cells, so whether antioxidants are beneficial for MTB infection is still under investigation. As a marker of MTB cell envelope (Lederer et al. 1975), does MA affect cells? Although a large body of literature has elucidated the structural mechanism of MA (Marrakchi et al. 2014), it is unclear whether NAC affects autophagy and apoptosis of MA-incubated RAW cells. In this study, RAW264.7 macrophages were used to explore further the immunological response


Polish Journal of Microbiology, Volume 69 , ISSUE 2, 223–229

research-paper | 12-August-2019

Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus

rather than a permanent damage. Therefore, the results directed us toward the investigation of the regenerative capacity of young brain, specifically regarding protein changes related to cell survival and apoptosis. In addition, we intended to look deeper into the potential molecular correlates of developmental deficits and/or delays and potential compensatory processes after fetal ethanol exposure. To do so in the rat model, we examined hippocampal expression and activation of selected proteins

Birsen Elibol, Merve Beker, Cigdem Dilek Sahbaz, Ulkan Kilic, Ewa Jakubowska-Doğru

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 133–147

Research paper | 10-October-2018

Hindlimb suspension-induced cell apoptosis in the posterior parietal cortex and lateral geniculate nucleus: corresponding changes in c-Fos protein and the PI3K/Akt signaling pathway

microgravity environment for 0 (Control group), 7, 14, or 28 days. We found a significant increase in cellular apoptosis in the PPC and the LGN after 7 days of simulated microgravity. In addition, there was an increase in expression of c-Fos protein in the PPC, and a repression of the PI3K/Akt signaling pathway in the LGN after 7 days. Based on these results, we conclude that short-term simulated microgravity may induce cell apoptosis in the PPC and LGN, and reflect a neural adaptive process to accommodate

Wei Huang, Chen Chen, Xufeng Liu

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 220–230

Research paper | 06-February-2018

Long-term consumption of fermented rooibos herbal tea offers neuroprotection against ischemic brain injury in rats

adult male Wistar rats. FRHT was administered to the animals ad libitum for 7 weeks prior to the induction of ischemic injury via a 20-minute bilateral occlusion of the common carotid arteries (BCCAO) followed by reperfusion for 24, 96 and 168 hours respectively. Neurobehavioural deficits, brain oedema, blood-brain barrier (BBB) damage, apoptosis, lipid peroxidation and total antioxidant capacity were subsequently evaluated using standard methods. Our results showed that long-term consumption of

Olusiji Akinrinmade, Sylvester Omoruyi, Daneel Dietrich, Okobi Ekpo

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 94–105

research-paper | 14-June-2019

Selective neuronal death following exposure to methylenedioxypyrovalerone is accompanied by an inhibition of NMDA receptor NR2B subunit expression

(developmentally comparable to the human fetus of the third trimester). Apoptosis in C57BL/6J mice 24 hours after i.p. injection of 10 mg/kg body weight of MDPV or vehicle (saline) was estimated by anti-caspase 3 (Casp3) immunohistochemistry and cell counting. The greatest percentage of increase in apoptotic cells was observed in the NAc. However, MDPV did not seem to increase apoptosis in adult mice (Ádám et al., 2014). Based on these observations, the mechanism of action appears to be developmentally

László István Gerecsei, Tamás Balázsa, Diego Echevarría, Ágota Ádám, Gergely Zachar, András Csillag

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 92–100

Mini Review | 15-March-2016

The Functions of Effector Proteins in Yersinia Virulence

innate immune system and cell death such as apoptosis, pyroptosis, and autophagy. Among the Yersinia effector proteins, YopB and YopD assist the injection of other virulence effectors into the host cytoplasm, while YopE, YopH, YopJ, YopO, and YopT target on disrupting host cell signaling pathways in the host cytosols. Many efforts have been applied to reveal that intracellular proteins such as Rho-GTPase, and transmembrane receptors such as Toll-like receptors (TLRs) both play critical roles in

Linglin Zhang, Meng Mei, Chan Yu, Wenwen Shen, Lixin Ma, Jiewang He, Li Yi

Polish Journal of Microbiology, Volume 65 , ISSUE 1, 5–12

original-paper | 28-June-2019

Analysis of the Amino Acid Sequence Variation of the 67–72p Protein and the Structural Pili Proteins of Corynebacterium diphtheriae for their Suitability as Potential Vaccine Antigens

to induce host cell death, giving a signal for apoptosis in the early stages of infection. The occurrence of 67–72p hemagglutinin is one of the characteristics of the potentially invasive strains because it can contribute to the cytotoxicity and apoptosis of the infected cells (Sabbadini et al. 2012). In our study, we analyzed the nucleotide and amino acid sequences of the genes encoding pili proteins which contribute to bacterial adherence to host cells, and also the gene encoding 67–72p protein


Polish Journal of Microbiology, Volume 68 , ISSUE 2, 233–246

research-article | 30-November-2019

Crocin acts as a neuroprotective mediator against methylphenidate-induced neurobehavioral and neurochemical sequelae: Possible role of the CREB-BDNF signaling pathway

22nd day, all animals were sacrificed and parameters for oxidative stress, inflammation, and apoptosis were measured in hippocampal tissues. Considering the importance of CREB signaling and its product, BDNF, the influence of crocin on MPH-induced disorders in the CREB signaling pathway was studied in hippocampal tissues (Carlezon Jr et al., 2005; Motaghinejad et al., 2016b; 2017d). Behavioral method Morris water maze task (MWM) The MWM apparatus includes a circular tank (160 cm in diameter and

Andia Ebrahimzadeh, Sara Yousefi Moghadam, Hanieh Rahimi, Majid Motaghinejad, Manijeh Motevalian, Sepideh Safari, Mobina Abbasi Mesrabadi

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 4, 352–366

research-article | 06-April-2020

Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells

nervous system (CNS) (Chen et al., 2013). It was found that BDNF has the capacity to treat neurological disorders (Nagahara and Tuszynski, 2011). When BDNF binds to its receptors, it activates a signaling pathway that leads to neural regeneration and the prevention of inflammatory responses and neuronal apoptosis (Chen et al., 2013). It is notable that BDNF is a vital signaling factor, due to its functions in neurogenesis, neuroprotection, axonal growth, myelination, and synaptic plasticity during

Zahra Baharvand, Mohammad Nabiuni, Mohammad Tahmaseb, Elaheh Amini, Sareh Pandamooz

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 38–46

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