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  • Immunohematology

 

Article | 17-February-2021

K antigens on neonatal red blood cells blocked by anti-K with titer of 32

were found to be due to a potent maternal anti-D that blocked D antigens on fetal RBCs, causing them to test as negative when typed with human IgM anti-D. Typing fetal RBCs with reagent antisera produced false-negative results, because all antigen sites were saturated by the antibody and unable to react with the antisera. This phenomenon is rare.7 Other blood group antibodies can also cause the blocking phenomenon; there are case reports of anti-K and anti-Fya8 that caused the blocked antigen

J. Novoselac, M. Raos, G. Tomac, M. Lukić, B. Golubić Ćepulić

Immunohematology, Volume 36 , ISSUE 2, 54–57

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