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  • Acta Neurobiologiae Experimentalis


research-paper | 30-November-2020

Estrogen receptor agonists induce anti-edema effects by altering α and β estrogen receptor gene expression

). Determining blood-brain barrier (BBB) disruption By evaluating the leakage of Evans blue (EB) dye, the degree of BBB disruption was measured, conforming to the O’Connor protocol (2005). Briefly, PBS 0.01 M with a concentration of 2% was used as EB dye solvent, then 2 ml/kg of dye as a BBB permeability detector was injected into the rat’s tail vein, 4 h after TBI. For removing the intravascular EB dye, rats were re-anesthetized 5 h with halothane and transcardiac perfusion was performed with 200 ml of

Mohammad Khaksari, Zahra Hajializadeh, Saeed Esmaeili Mahani, Zahra Soltani, Gholamreza Asadikaram

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 3, 286–294

research-article | 06-April-2020

Neuroprotective effect of poly(lactic-co-glycolic acid) nanoparticle-bound brain-derived neurotrophic factor in a permanent middle cerebral artery occlusion model of ischemia in rats

carrier to cross the blood brain barrier (BBB) and deliver BDNF to target cells will revolutionize the medical field. This technology could be applied to other neurological conditions, such as hypoxic ischemic insults, depression, Parkinson’s disease, and Alzheimer’s disease, in which BDNF has been proven beneficial using in vivo experiments (Nagahara and Tuszynski, 2011). Many studies have evaluated the effect of BDNF in hypoxic ischemia. Thus, it was beneficial to assess if BDNF could be

Siti Norsyafika Kamarudin, Igor Iezhitsa, Minaketan Tripathy, Renad Alyautdin, Nafeeza Mohd Ismail

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 1–18

Research paper | 06-February-2018

Long-term consumption of fermented rooibos herbal tea offers neuroprotection against ischemic brain injury in rats

adult male Wistar rats. FRHT was administered to the animals ad libitum for 7 weeks prior to the induction of ischemic injury via a 20-minute bilateral occlusion of the common carotid arteries (BCCAO) followed by reperfusion for 24, 96 and 168 hours respectively. Neurobehavioural deficits, brain oedema, blood-brain barrier (BBB) damage, apoptosis, lipid peroxidation and total antioxidant capacity were subsequently evaluated using standard methods. Our results showed that long-term consumption of

Olusiji Akinrinmade, Sylvester Omoruyi, Daneel Dietrich, Okobi Ekpo

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 94–105

Research Article | 21-May-2019


well-described. Borrelia burgdorferi spirochetes are considered as one of the most invasive mammalian pathogen. They are able to move through the skin, as well as break into and out of blood vessels, easily crossing the blood-brain barrier. Genes encoding various motility forms are bound with chemotaxis signaling system which leads and coordinates motion functions. The attachment of bacteria to host cells or extracellular matrix may promote colonization and disease development. Lyme disease

Tomasz Chmielewski, Stanisława Tylewska-Wierzbanowska

Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 1, 100–105

research-article | 30-November-2020

Regular aerobic exercise increased VEGF levels in both soleus and gastrocnemius muscles correlated with hippocampal learning and VEGF levels

, VEGF can also cross the blood-brain barrier (Fournier and Duman, 2012; Ballard, 2017). Additionally, muscle fiber type is a determining factor for VEGF production in exercising muscles (Birot et al., 2003). It is unknown whether there is a relationship between muscle fiber type-specific VEGF levels and learning/memory. The aim of this study is to investigate the relationship between hippocampus-dependent memory function and fiber type-specific VEGF levels and to determine if antioxidant status

Asli Karakilic, Oguz Yuksel, Servet Kizildag, Ferda Hosgorler, Birsu Topcugil, Rabia Ilgin, Hikmet Gumus, Guven Guvendi, Basar Koc, Sevim Kandis, Mehmet Ates, Nazan Uysal

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 1–9

Research paper | 25-July-2017

Pharmacokinetics and pharmacodynamics of a novel Acetylcholinesterase Inhibitor, DMNG-3

distribution tissues of DMNG-3 in mice. It was found that DMNG-3 could be detected in brain, suggesting that DMNG-3 can cross the blood-brain barrier. The present study shows that DMNG-3 can be possible developed as a new drug for the treatment of Alzheimer’s disease in the future.

Xin-Guo Zhang, Fei Kou, Guo-Di MA, Peng Tang, Zhong-Duo Yang

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 2, 117–124

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