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Report | 06-November-2019

Drugs that have been shown to cause druginduced immune hemolytic anemia or positive direct antiglobulin tests: some interesting findings since 2007

This review updates new findings in drug-induced immunehemolytic anemia (DIIHA) since the 2007 review in Immunohematology by these authors. Twelve additional drugs  have been added to the three tables listing drugs associated with drug-dependent antibodies, drugs associated with drug-independent antibodies, and drugs associated with nonimmunologic protein adsorption. Other updated findings include (1) piperacillin is currently the most commonly encountered cause of DIIHA, (2) new data on

George Garratty, Patricia A. Arndt

Immunohematology, Volume 30 , ISSUE 2, 66–79

Research paper | 06-February-2018

The differential effects of neuroleptic drugs and PACAP on the expression of BDNF mRNA and protein in a human glioblastoma cell line

It has been suggested that, in addition to modulation of monoaminergic neurotransmission, antipsychotic drugs can also affect expression of neurotrophic factors in the brain. The present study was aimed to examine the effects of the first generation neuroleptic drug (FGA; haloperidol) and second generation neuroleptic drugs (SGAs; olanzapine and amisulpride) on expression and level of brain-derived neurotrophic factor (BDNF) in astrocyte-like T98G glioblastoma cell line. Effects of these drugs

Marta Jóźwiak-Bębenista, Magdalena Jasińska-Stroschein, Edward Kowalczyk

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 3, 205–213

Research paper | 01-August-2017

The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch

animal model of itch differentiates itch or pain to show efficacy of clinically effective analgesic drugs as a back translation. In this study, we explored the effects of different group of analgesic drugs on serotonin and compound 48/80-induced scratching behavior in Balb-C mice. Serotonin (25 μg) and compound 48/80 (100 μg) was injected intradermally in a volume of 50 μl into the rostral part of skin on the back of male mice and scratches were counted for a 30-min observation period. Morphine (1, 3

Fatih Ilkaya, Ozgur Yesilyurt, Melik Seyrek, Ozgur Gunduz, Tayfun Ide, Ahmet Akar, Ahmet Ulugol, Hasan Guzel, Ahmet Dogrul, Durmus Ucar, Caner Gunaydin

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 3, 234–243

Review Paper | 10-December-2015

Antiepileptic drugs as a new therapeutic concept for the prevention of cognitive impairment and Alzheimer’s disease. Recent advances

Introduction. Excessive accumulation of amyloid-beta (A_) peptides in the brain results initially in mild cognitive impairment (MCI) and finally in Alzheimer’s disease (AD). Evidences from experimental and clinical studies show that pathological hyperexcitability of hippocampal neurons is a very early functional impairment observed in progressive memory dysfunctions. Therefore, antiepileptic drugs (AEDs) whose mechanism of action is aimed at inhibition of such neuronal hyperexcitability

Krzysztof Sendrowski, Wojciech Sobaniec

Journal of Epileptology, Volume 23 , ISSUE 2, 139–147

Review Paper | 06-April-2016

Anticonvulsant therapy in brain-tumor related epilepsy

seizures does not differ substantially from that applied to epilepsies from other etiologies. Therefore, the choice of an AED is based, above all, on tolerability and pharmacokinetic interactions with chemotherapeutic drugs. Levetiracetam is recommended by many authors as first-line therapy in brain tumor-related epilepsy. Due to the possibility of interactions, the combination of enzyme-inducing AEDs and chemotherapeutic drugs, is usually not recommended as a first choice. Currently there is no

Walter Fröscher, Timo Kirschstein, Johannes Rösche

Journal of Epileptology, Volume 24 , ISSUE 1, 41–56

Review Paper | 26-March-2014

Selected classical and novel antiepileptic drugs – mechanisms of action, neuroprotection, and effectiveness in epileptic and non-epileptic conditions

drugs (AEDs – lamotrigine, topiramate, levetiracetam, valproate and carbamazepine). Methods. A literature search for publications written in English, preferably published within a period of the last fifteen years, using the key words listed below. Review. The majority of AEDs possess more than one mechanism of action. They exert their effect by acting on various receptors (different types of glutamatergic and mainly GABAA receptors), neurotransmitters (mainly glutamate or GABA) and voltage

Magdalena Chrościńska-Krawczyk, Magdalena Wałek, Bożydar Tylus, Stanisław J. Czuczwar

Journal of Epileptology, Volume 22 , ISSUE 1, 37–50

research-article | 24-June-2021

Selected flavonoids and their role in the treatment of epilepsy – a review of the latest reports from experimental studies

properties as adjuncts to standard antiepileptic drugs in the DRE treatment and flavonoids and may be a potential group of natural drugs that increase the effects of commonly used anticonvulsants. Flavonoids, a class of secondary plant metabolites, have been shown to demonstrate a wide spectrum of biological activity, among others antioxidant (Santos et al., 1999), anti-inflammatory (Pintho et al., 2016), anti-allergic (Kawai et al., 2006), antiatherosclerotic (Goldwasser et al., 2011), antidiabetic

Joanna Szala-Rycaj, Mirosław Zagaja, Aleksandra Szewczyk, Marta Andres-Mach

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 2, 95–104

Hypothesis | 30-August-2017

Do minocycline and other suppressors of microglia reactivity have a future in prevention or treatment of epilepsy?

potential usefulness of microglia regulators and anti-inflammatory agents in designing antiepileptic/antiepileptogenic drugs, with the primary mechanism of action based on the inhibition of neuroinflammation. Methods. We reviewed PubMed and MEDLINE databases to select publications in the topic: epilepsy, neuroinflammation, microglia and microglia regulators with antiepileptic properties. We searched the databases up to April 2017 with no date restrictions. Review and Discussion. In the present paper, we

Władysław Lasoń, Joanna Ślusarczyk, Magdalena Regulska, Monika Leśkiewicz, Agnieszka Basta-Kaim

Journal of Epileptology, Volume 25 , ISSUE 1-2, 9–20

review-article | 02-July-2019

Rational polytherapy: Myth or reality?

antiepileptic drugs (AEDs) was based on the avoidance of combined pharmacodynamic or pharmacokinetic side effects (French and Faught, 2009). In the ninth decade of the twentieth century, the so-called second-generation antiepileptic drugs (SGAEDs) started being commercialized. They had the advantages of better pharmacokinetic and pharmacodynamic profiles, less side effects and fewer drug interactions when compared with their first generation counterparts. Furthermore, several of them had novel mechanisms of

José Pimentel, José Manuel Lopes Lima

Journal of Epileptology, Volume 27 , 27–34

Article | 30-November-2018


immunosuppressive treatment, patients on hemodialysis, and newborns due to the immaturity of the immune system [6, 7, 18, 31, 35, 36]. The currently available, approved and certified diagnostic methods allow for a quick and reliable confirmation of the infection, demonstration of viral replication, monitoring of the course of the infection and result in effective antiviral therapy. However, despite the diagnostic and therapeutic solutions in the form of antiviral drugs, the hCMV is still a significant cause of

Anna Majewska, Beata Młynarczyk-Bonikowska, Magdalena Malejczyk, Sławomir Majewski, Grażyna Młynarczyk

Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 3, 291–299

research-paper | 12-August-2019

Coumarins as potential supportive medication for the treatment of epilepsy

effect of coumarins on the central nervous system (CNS). Therefore, numerous experimental studies focus on disorders such as epilepsy, schizophrenia, depressive and anxiety disorders or Alzheimer’s disease (Skalicka-Woźniak et al., 2016). Possible anticonvulsant properties of natural coumarins Epileptic seizures are the result of excessive abnormal neuronal activity in the brain. The primary treatment for epilepsy is the administration of antiepileptic drugs (AEDs). These drugs reduce the frequency

Jarosław Bryda, Mirosław Zagaja, Aleksandra Szewczyk, Marta Andres-Mach

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 2, 126–132

research-article | 30-November-2018

Cell-based immunofluorescence assay for screening the neurogenesis potential of new drugs in adult hippocampal neural progenitor cells

); optical detection methods, such as colorimetric, luminescent, or fluorescent methods (e.g. MTT assay and cell-based ELISA) (Zang et al., 2012; Kohl and Ascoli, 2017); and high-throughput image analysis. This method uses high-throughput fluorescence and confocal microscopes with advanced analysis software (Nierode et al., 2016). Here, we described a simple, rapid cell-based immunofluorescence assay for screening the potential of new drugs to promote neurogenesis of adult hippocampal neural progenitor

Kun Zhang, Bin Li, Peifang Li, Xiaoli Yang, Huixian Cui, Xiaoyun Liu

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 3, 303–309

original-paper | 05-December-2019

Inhibition of Drug Resistance of Staphylococcus aureus by Efflux Pump Inhibitor and Autolysis Inducer to Strengthen the Antibacterial Activity of β-lactam Drugs

. 2009; Kolendi 2010). MRSA infection is always associated with chronic or recurrent infections, including osteomyelitis, pulmonary infection, and endocardial inflammation (Que et al. 2005). In China, almost 10% of S. aureus clinical isolates were considered resistant to penicillin in recent years (Hu et al. 2016; Chen et al. 2017). Several new targets have been discovered and addressed in recent drugs, including ClpP protease and FtsZ of the cell division machinery. Resistance can be modified and


Polish Journal of Microbiology, Volume 68 , ISSUE 4, 477–491

Report | 06-November-2019

How we investigate drug-induced immune hemolytic anemia

Drugs are a rare cause of immune hemolytic anemia, but an investigation for a drug antibody may be warranted if a patient has definitive evidence of immune hemolysis, other more common causes of hemolysis have been excluded, and there is a good temporal relationship between the administration of a drug and the hemolytic event. Drug antibodies are either drug-dependent (require drug to be in the test system) or drug-independent (reactive without drug present in the test). Drug-dependent

Regina M. Leger, Patricia A. Arndt, George Garratty

Immunohematology, Volume 30 , ISSUE 2, 85–94

Report | 06-November-2019

Drug-induced immune hemolytic anemia: the last 30 years  of changes

, such as which drugs most commonly cause DIIHA, the optimal testing methods for identifying them, and the theories behind the mechanisms by which they react. This article reviews the major changes in DIIHA since the early 1980s involving the immune complex mechanism, cephalosporins, nonimmunologic protein adsorption, and penicillins. Because serologic results associated with DIIHA can mimic those expected with autoimmune hemolytic anemia or hemolytic transfusion reactions, DIIHA may go undetected in

Patricia A. Arndt

Immunohematology, Volume 30 , ISSUE 2, 44–54

research-article | 18-December-2018

Determinants of medication withdrawal strategy in the epilepsy monitoring unit*

(Cox et al., 2017). Monitoring can be used in patients with infrequent events, and tapering antiepileptic drugs (AEDs) has a beneficial effect on seizure frequency in this population (Al Kasab et al., 2016). There is little consensus regarding the best AED withdrawal regimen during VEEG. A recent survey of epilepsy monitoring units (EMUs) revealed 80% of centers do not have a protocol for medication taper, and withdrawal is generally done on a case by case basis (Buelow et al., 2009). Guld et al

Alendia Hartshorn, Yasser Shahrour, Angeline S. Andrew, Krzysztof Bujarski

Journal of Epileptology, Volume 26 , ISSUE 1-2, 15–19

research-article | 15-October-2020

Antistress and antidepressant properties of dapoxetine and vortioxetine

examine an antidepressant efficacy of DAP, VOR, and the combination of those drugs as well as the level of corticosterone release after drug administration in the stressed rats. METHODS Animals and treatments 48 male Wistar rats were housed in cages (size 31 × 30 × 15 cm) in a light (lights on 07:00–19:00 h), temperature- and humidity-controlled animal facility. All procedures related to the use of rats in these experiments were conducted with due respect to ethical principles regarding experiments

Piotr Ratajczak, Krzysztof Kus, Małgorzata Zielińska-Przyjemska, Beata Skórczewska, Tomasz Zaprutko, Dorota Kopciuch, Anna Paczkowska, Elżbieta Nowakowska

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 217–224

research-paper | 14-June-2019

Antidepressant and anxiolytic efficacy of single, chronic and concomitant use of vortioxetine, dapoxetine and fluoxetine in prenatally stressed rats

corticosterone levels (Van den Hove et al., 2005), is an effective method for achieving an animal model of depression. Polypharmacotherapy, i.e., the combined use of drugs, is frequently utilized in the treatment of depression. Usually, the effects of an anti-depressant agent are discernable after 2–4 weeks of pharmacotherapy (Machado-Vieira et al., 2010), which is why they are increasingly used in combination therapy in an attempt to achieve the effect earlier. Apart from offering undoubted advantages

Piotr Ratajczak, Krzysztof Kus, Tomasz Zaprutko, Mikołaj Szczepański, Sandra Rusowicz, Elżbieta Nowakowska

Acta Neurobiologiae Experimentalis, Volume 79 , ISSUE 1, 13–24

Review Paper | 18-December-2014

Failure of a first regimen of monotherapy to control the newly diagnosed epilepsies. What to do next?

José Pimentel

Journal of Epileptology, Volume 22 , ISSUE 2, 109–112

Original Paper | 10-December-2018

Drug Susceptibility of Non-tuberculous Strains of Mycobacterium Isolated from Birds from Poland

antituberculous drugs most commonly used in the treatment of mycobacterial infections in humans. For drug susceptibility tests, drugs such as isoniazid, rifampicin, streptomycin, ethambutol, ofloxacin, capreomycin, cycloserine and ethionamide were used. A high degree of drug resistance was demonstrated, particularly in Mycobacterium avium. Isolates of Mycobacterium xenopi showed a relatively good susceptibility to the drugs tested. The drug resistance of Mycobacterium genavense has not been determined, but


Polish Journal of Microbiology, Volume 67 , ISSUE 4, 487–492

minireview | 24-February-2021

The Pathogenesis of Aspergillus fumigatus, Host Defense Mechanisms, and the Development of AFMP4 Antigen as a Vaccine

drugs, they failed to provide satisfying treatment for invasive aspergillosis patients. Notably, the clear side effects of antifungal drugs such as amphotericin B’s kidney toxicity and the potential hepatotoxicity of itraconazole discouraged their clinical use. Although voriconazole had better penetration than amphotericin B and itraconazole, it might cause temporary hepatotoxicity. In addition to the side effects of antifungal drugs, drug resistance and high cost also greatly hindered the use of


Polish Journal of Microbiology, Volume 70 , ISSUE 1, 3–11

Report | 06-November-2019

Drug-induced immune neutropenia/ agranulocytosis

untreated can result in death. Treatment with granulocyte colony-stimulating factor can hasten neutrophil recovery. Cumulative data show that severe neutropenia or agranulocytosis associated with exposure to nonchemotherapy drugs ranges from approximately 1.6 to 15.4 cases per million population per year. Drugs most often associated with neutropenia or agranulocytosis include dipyrone, diclofenac, ticlopidine, calcium dobesilate, spironolactone, antithyroid drugs (e.g., propylthiouracil), carbamazepine

Brian R. Curtis

Immunohematology, Volume 30 , ISSUE 2, 95–101

research-article | 30-November-2019

The effectiveness of changes to drug policy, regulation and legislation for reducing harms associated with opioids and supporting their medicinal use in Australia, Canada and the UK: A systematic review

application. Our research suggests that an approach to reducing problems with opioids and supporting their medicinal use requires actions beyond drug policy changes, including more research and evaluation, awareness-raising and investment in appropriate treatment and health care. For the purposes of this review, the term ‘drug policy’ is generally used to describe legislation, regulation and policy systems and mechanisms and frameworks that make available and monitor the use of opioid drugs. In some cases

Ben O’Mara

Evidence Base, Volume 2020 , ISSUE 2, 79–110

Review | 22-November-2020

Review: immune hemolytic anemia and/or positive direct antiglobulin tests caused by drugs

George Garratty

Immunohematology, Volume 10 , ISSUE 2, 41–50

Review | 10-October-2018

Role of food-drug interactions in neurological and psychological diseases

Given that foods and nutrients have been shown to influence the pharmacokinetics of drugs, drugs may cause changes in the nutritional status of patients and their response to a given drug. Food-drug interactions are particularly relevant for drugs used to treat neurological and psychological diseases. This review provides an overview of food-drug interaction in the treatment of neurological and psychological diseases. A literature search was carried out by collecting data from different reviews

Makbule Gezmen-Karadağ, Elif Çelik, Fatma Zehra Kadayifçi, Özge Yeşildemir, Yasemin Ertaş Öztürk, Duygu Ağagündüz

Acta Neurobiologiae Experimentalis, Volume 78 , ISSUE 3, 187–197

minireview | 21-June-2021

Emerging Applications of Bacteriocins as Antimicrobials, Anticancer Drugs, and Modulators of The Gastrointestinal Microbiota

in modifying some metabolic pathways that, in turn, regulate cell proliferation, apoptosis, differentiation, angiogenesis, inflammation, and metastasis, which are relevant aspects to prevent the development of cancer (Bermudez-Brito et al. 2012). Bacteriocins have shown cytotoxic activity against cancer cells, and therefore they could be considered tools to develop new anticancer drugs (Baindara et al. 2018). The charge of normal cell membranes is neutral, while cancer cells have a negative


Polish Journal of Microbiology, Volume 70 , ISSUE 2, 143–159

Article | 17-November-2020

Detection of drug-dependent platelet antibodies by use of solid-phase red cell adherence techniques

Many drugs have been reported to cause drug-dependent thrombocytopenia, either by the immune complex or by hapten mechanisms. Testing for the presence of these platelet antibodies has not been considered feasible for transfusion services because their presence was thought to be rare, and their detection involved complex and costly methods. We have developed a new technique for detection of these antibodies that can be performed without the need for specialized and expensive instrumentation. A

Miriam F. Leach, Linda K. Cooper, James P. AuBuchon

Immunohematology, Volume 11 , ISSUE 4, 143–149

research-article | 27-March-2019

Recommendations of the Polish Society of Epileptology for the treatment of epileptic seizure in adult patients in Poland: an update

-line AEDs, used usually as first in the therapy. If the chosen drug does not give the expected beneficial effect (lack of efficacy and/or side effects), another drug out of first line category can be used (an alternative monotherapy). Depending on the clinical situation, alternative monotherapies with first-line drugs or add-on therapy may be introduced. Add-on therapy – a therapeutic option in which another drug from the first or second and third line drugs is added to the first-line drug. The

Joanna Jędrzejczak, Beata Majkowska-Zwolińska, Danuta Ryglewicz, Ewa Nagańska, Maria Mazurkiewicz-Bełdzińska

Journal of Epileptology, Volume 27 , 9–16

original-paper | 29-May-2020

A Current Microbiological Picture of Mycobacterium Isolates from Istanbul, Turkey

), growth on the solid or liquid media, and biochemical tests continue to play significant roles in the identification of mycobacteria (Kurtoglu et al. 2011). Treatment and prophylaxis of tuberculosis differ from most other bacterial infections. In general, patients should receive multiple antibiotic treatments for at least 6 to 9 months (Ozmen et al. 2017). The World Health Organization (WHO) recommends the combined use of 1st-line drugs in the initial treatment of tuberculosis. However, anti


Polish Journal of Microbiology, Volume 69 , ISSUE 2, 185–191

Research Article | 23-May-2019


The constantly growing number of multidrug-resistant bacterial strains prompts the search for alternative treatments. Synthetic peptides based on natural antimicrobial peptides, also known as antimicrobial lipopeptides, can become a promising group of “drugs” to fight multi-resistant bacteria. The present paper discusses the origins of synthetic lipopeptides, their classification and antimicro- bial properties.

Paulina Czechowicz, Joanna Nowicka

Postępy Mikrobiologii - Advancements of Microbiology, Volume 57 , ISSUE 3, 213–227

Case report | 06-November-2019

Diagnostic pitfalls of drug-induced immune hemolytic anemia

Immune hemolytic anemia (IHA) is a rare complication of drug administration. However, its true incidence remains obscure, as there are a number of factors that may lead to misdiagnosis. The clinical and serologic pictures are variable, and there is a great deal of unawareness that certain drugs can cause IHA. Furthermore, serologic results can be easily misinterpreted, resulting in a wrong diagnosis.

Abdulgabar Salama, Beate Mayer

Immunohematology, Volume 30 , ISSUE 2, 80–84

Article | 14-October-2020

Practical aspects of investigating drug-induced immune hemolytic anemia due to cefotetan or ceftriaxone - a case study approach

In the 1970s, the most common causes of drug-induced immune hemolytic anemia were methyldopa and penicillin. Since 1990, the most common causes of drug-induced immune hemolytic anemia have been the second- and third-generation cephalosporins, cefotetan and ceftriaxone. Three case histories illustrate the common findings in the serologic investigation of immune hemolytic anemias due to these two drugs.

Patricia A. Arndt

Immunohematology, Volume 18 , ISSUE 2, 27–32

Research paper | 06-February-2018

Tiapride prevents the aversive but not the rewarding effect induced by parabrachial electrical stimulation in a place preference task

The parabrachial complex has been related to the processing of both rewarding and aversive signals. This pontine area is activated after the gastrointestinal administration of rewarding nutrients, in taste aversion learning, and in response to the reinforcing and aversive effects of some drugs of abuse. Electrical stimulation of this region can induce, in different animals, preference or aversion behaviors towards a place in a rectangular three-chamber maze task. This study examined the effect

María M. Hurtado, Raquel García, Amadeo Puerto

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 3, 236–243

Review | 25-July-2017

Lithium – therapeutic tool endowed with multiple beneficiary effects caused by multiple mechanisms

Mood disorders are relatively common serious human diseases for which there is often no ideal pharmacotherapy. Basic characteristic of these diseases is affective disorder shifting the mood of the patient to depression (together with anxiety or not) or towards to euphoria. Available drugs are usually divided into two groups – mood stabilizers, which are used primarily to treat bipolar disorder,and antidepressants for the treatment of unipolar depression. Lithium is still recommended as the

Miroslava Vosahlikova, Petr Svoboda

Acta Neurobiologiae Experimentalis, Volume 76 , ISSUE 1, 1–19

Research paper | 06-February-2018

Marble burying as compulsive behaviors in male and female mice

receptor or a “pure” inhibitor of the serotonin transporter, escitalopram, that has been reported to be particularly effective in OCD. A burying paradigm that more precisely mimics the human condition was used, e.g., testing in the home environment, chronic drug exposure and acknowledging individual differences by pre-selecting for high marble burying. Results were that there were no sex differences in groups treated with drugs or in control mice. Both diazepam and escitalopram decreased numbers of

George T. Taylor, Sandra Lerch, Sabine Chourbaji

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 3, 254–260

Mini Review | 30-June-2018

Non-antibiotics, Efflux Pumps and Drug Resistance of Gram-negative Rods

Non-antibiotic medicinal products consist of drugs with diverse activity against bacteria. Many non-antibiotics demonstrate direct anti-bacterial activity against Gram-positive cocci. The activity observed against Gram-negative rods is much lower and non-antibiotics primarily from the following groups: non-steroidal anti-inflammatory drugs, cardiovascular and antidepressant medicinal products demonstrate this activity. It has been shown that the low activity of some non-antibiotics or the


Polish Journal of Microbiology, Volume 67 , ISSUE 2, 129–135

Original Paper | 22-December-2016

Additive interactions between retigabine and oxcarbazepine in the chimney test and the model of generalized tonic-clonic seizures in mice

Introduction. Patients with pharmacoresistant epilepsy are usually treated with two or more antiepileptic drugs (AEDs). The search for therapeutically efficacious AED combinations is still a challenging issue for clinicians and epileptologists throughout the world. Aim. To determine the interaction profile for the combination of retigabine (RTG) and oxcarbazepine (OXC) in both, the model of tonic-clonic seizures, the maximal electroshock (MES)-induced seizure model and chimney test (motor

Mirosław Zagaja, Barbara Miziak, Katarzyna Załuska, Paweł Marzęda, Bartłomiej Drop, Karolina Załuska-Patel, Grażyna Ossowska, Stanisław J. Czuczwar, Jarogniew J. Łuszczki

Journal of Epileptology, Volume 24 , ISSUE 2, 87–94

Article | 10-June-2019


antibiotics with drugs inhibiting cell wall synthesis – mainly ampicillin [19]. In addition, enterococci have naturally increased resistance to penicillins – in comparison to streptococci, they are from 10 to even 100 times less sensitive to β-lactam antibiotics (E. faecalis), while E. faecium is 4–16 times less sensitive than E. faecalis [1, 4, 19]. This is associated with the overexpression of PBP5 proteins (penicillin binding proteins), very often found in E. faecium, and much less frequently in the

Wojciech Rogóż, Daniel Sypniewski, Ilona Bednarek

Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 1, 35–48

Research Article | 15-February-2020

Inspection of Solid Dosage Forms using  THz Imaging Spectroscopy

The present work describes a laboratory terahertz (THz) imaging spectroscopy system and its possibilities to inspect solid dosage forms in the form of coated tablets and capsules. Moreover, the chemical composition and layer structure of coated pharmaceutical tablets are investigated. These chemical and physical properties of solid dosage forms can be used for the detection of counterfeit drugs. Preliminary results show that THz time domain spectroscopy and imaging is a promising technology for

T. Arnold, M. De Biasio, A. Fritz, R. Leitner

International Journal on Smart Sensing and Intelligent Systems, Volume 7 , ISSUE 5, 1–4

research-article | 26-March-2021

Interaction of agonists of a different subtype of the nAChR and carvacrol with GABA in Ascaris suum somatic muscle contractions

potentially a very attractive drug target (Trailovic and Varagic, 2007). The most commonly used antinematodal drugs in human and veterinary medicine are cholinergic agonists: imidazothiazole (levamisole), tetrahydropyrimidines (pyrantel, morantel and oxantel), quaternary/tertiary amines (bephenium and tribendimidine), pyridines (methyridine), and amino-acetonitrile derivatives (AADs; monepantel). This group of drugs produces spastic paralysis of the nematode by selectively gating acetylcholine receptor

Djordje S. Marjanović, Saša M. Trailović, Mirjana Milovanović

Journal of Nematology, Volume 53 , 1–8

Article | 30-November-2018


Sylwia Joanna Chmielewska, Katarzyna Leszczyńska

Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 3, 271–289

Case report | 09-October-2019

Development of red blood cell autoantibodies following treatment with checkpoint inhibitors: a new class of anti-neoplastic, immunotherapeutic agents associated with immune dysregulation

Ipilimumab, nivolumab, and pembrolizumab represent a new class of immunotherapeutic drugs for treating patients with advanced cancer. Known as checkpoint inhibitors, these drugs act to upregulate the cellular and humoral immune response to tumor antigens by inhibiting T-cell autoregulation. As a consequence, they can be associated with immune-related adverse events (irAEs) due to loss of self-tolerance, including rare cases of immune-related cytopenias. We performed a retrospective clinical

Laura L.W. Cooling, John Sherbeck, Jonathon C. Mowers, Sheri L. Hugan

Immunohematology, Volume 33 , ISSUE 1, 15–21

Article | 06-December-2020

Serologic investigation of fatal hemolytic anemia associated with a multiple drug history and Rh-like autoantibody

of three chemically similar nonsteroidal anti-inflammatory drugs: tolmetin (Tolectin®), sulindac (Clinoril®), and ketorolac (Toradol®). Only tolmetin and furosemide (Lasix®) antibodies were demonstrable in the patient's serum at the time of her final admission. The patient's serum at final admission contained panagglutinating IgG and IgM antibody with a titer of 1:80 using a pool of R1R1 and R2R2 screening cells. When tolmetin was added to the test system, the titer

Nancy I. Maddox, Debra Futral, Floyd T. Boudreau

Immunohematology, Volume 8 , ISSUE 3, 70–76

Research Article | 24-November-2017

Smoking as an early risk factor for problematic parenting practices

Parenting among those who use non-illicit and more common drugs such as cigarettes remains an understudied area for investigation. Secondary data analyses were performed in 2015 on a prospective study with parent and twin data available on n=3,009 individual members of female twin pairs born between July 1975 and June 1985 identified from Missouri-state birth records. Maternal smoking when the twins were 3+ years of age remained a significant predictor of offspring report of childhood sexual

Mini Tandon, Julia D. Grant, Pamela A.F. Madden, Kathleen K. Bucholz, Andrew C. Heath

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 5 , ISSUE 2, 52–54

short-communication | 07-June-2021

Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland – a Pilot Study

The number of bacterial isolates extremely resistant to previously effective drugs is growing dynamically. Infections are increasingly being caused by pathogens that are not susceptible to all available antibiotics. This issue is particularly acute for Gram-negative bacilli, both the Enterobacterales strains and non-fermenting rods. Colistin is used as one of the last available treatment options for patients with severe infections caused by carbapenem-resistant Gram-negative rods. Due to the


Polish Journal of Microbiology, Volume 70 , ISSUE 2, 283–288

Review Paper | 30-November-2015

The role of cannabinoids and endocannabinoid system in the treatment of epilepsy

Introduction. The treatment of epilepsy is still a major challenge. Despite the introduction of many new antiepileptic drugs, approximately 30% of patients still remain drug resistant. In the absence of a satisfactory therapy outcome, which is sometimes associated with numerous side effects, there is a need for new and effective drugs with low toxicity. Cannabinoids have been shown in preliminary animal model studies and in studies of patients with epilepsy to have antiepileptic activity. Aim

Monika Pędracka, Jacek Gawłowicz

Journal of Epileptology, Volume 23 , ISSUE 2, 131–138

case-report | 25-November-2020

Pharmacoresistant epilepsy associated with mutations in the KCNB1 and RELN genes. A case report

INTRODUCTION Epilepsy is one of the most common neurological diseases worldwide and is considered a major public health problem, with socioeconomic problems (Camfield and Camfield, 2015; López González et al., 2015). Generally, this disease can be successfully treated in most cases. However, there is a high percent of patients that does not respond favorably to common antiepileptic drugs (AED) despite the continued development of new AED the last two decades, resulting in pharmacoresistance

Adamantios Katerelos, Nikolaos Zagkos, Dimitra Alexopoulou, Stella Mouskou, Anastasia Korona, Emmanouil Manolakos

Journal of Epileptology, Volume 28 , 73–77

research-article | 06-April-2020

Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells

various CNS disorders (Harvey et al., 2015). Drugs that can upregulate the expression of BDNF and its downstream effectors, such as the phosphoinositide 3-kinase (PI3K) pathway, the mitogen-activated protein kinase (MAPK) pathway, and the cAMP response element-binding protein (CREB), are suitable options for the treatment of neurodegenerative disorders (Yoshii and Constantine-Paton, 2010; Lin et al., 2016). GDNF is another neurotrophic factor that is released from glial cells and has several effects

Zahra Baharvand, Mohammad Nabiuni, Mohammad Tahmaseb, Elaheh Amini, Sareh Pandamooz

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 38–46

Report | 06-November-2019

Drug-induced immune thrombocytopenia: incidence, clinical features, laboratory testing, and pathogenic mechanisms

Drug-induced immune thrombocytopenia (DIIT) is a relatively uncommon adverse reaction caused by drug-dependent antibodies (DDAbs) that react with platelet membrane glycoproteins only when the implicated drug is present. Although more than 100 drugs have been associated with causing DIIT, recent reviews of available data show that carbamazepine, eptifibatide, ibuprofen, quinidine, quinine, oxaliplatin, rifampin, sulfamethoxazole, trimethoprim, and vancomycin are probably the most frequently

Brian R. Curtis

Immunohematology, Volume 30 , ISSUE 2, 55–65

Article | 14-October-2020

Drug-dependent antibodies with immune hemolytic anemia in AIDS patients

two, and one patient had RBC-bound C3d only. No drug-independent antibodies were detected. Our study demonstrates that patients with AIDS commonly develop D-DAbs. D-IHA should be included in the differential diagnosis of a falling Hb in AIDS patients receiving drugs.

Carlos A. González, Liliana Guzmán, Gabriela Nocetti

Immunohematology, Volume 19 , ISSUE 1, 10–15

Mini Review | 04-September-2018

Are Probiotic Really Safe for Humans?

Probiotic bacteria have been used as a health-promoting factor for a very long time. Nowadays, products containing probiotic bacteria are becoming more and more popular on the market. The term probiotics refers to the products belonging to the following groups: probiotic drugs (medicinal products – live biotherapeutic products for human use), medical devices, probiotic foods (e.g. foods, food ingredients, dietary supplements or food for special medical purposes), directly fed microorganisms


Polish Journal of Microbiology, Volume 67 , ISSUE 3, 251–258

review-article | 15-October-2020

Modulation of anxiety behavior in gonadectomized animals

clear understanding of the neural mechanisms underlying their etiology. Understanding the effect of hormones on the neurobiological systems which modulate anxiety behavior will increase our capacity to develop new drug targets to treat several mental illnesses in humans (McHenry et al., 2014). In fact, animal behavioral profiles are usually employed to evaluate new therapeutic agents to treat anxiety disorders and to evaluate the mechanism of action of anxiolytic drugs (Siepmann and Joraschky, 2007

Roghaieh Khakpay, Fatemeh Khakpai

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 205–216

Case report | 15-June-2016

Concomitant treatment with imipenem causes a rapid and extensive decrease in the plasma concentrations of valproic acid

Background. Valproic acid (VPA) is a wide-spectrum antiepileptic drug used both in children and in adults. We describe a clinically important interaction between VPA and imipenem, a carbapenem antimicrobial. Case presentation. Our patient was a 19-year-old man with childhood onset of mental retardation and severe epilepsy. He was hospitalized due to pneumonia. His antiepileptic drugs, including VPA, were administered intravenously. Due to pneumonia, intravenously administered imipenem was

Tapani Keränen, Hanna Kuusisto

Journal of Epileptology, Volume 24 , ISSUE 1, 63–66

Research Article | 23-May-2019


patients are far more likely to develop proliferative diseases caused by EBV or HHV-8. This problem also applies to HIV-positive individuals co-infected with EBV or HHV-8. Gammaherpesviruses can also be the cause of post-transplantation issues in patients on immunosuppressive drugs and EBV is known to induce severe clinical syndromes in people with specific genetic disorders. Presented article summarizes epidemiology, pathogenesis, clinical syndromes and treatment of EBV and HHV-8 in individuals with

Anna Żuk-Wasek, Natalia Żeber, Grażyna Młynarczyk, Maciej Przybylski, Tomasz Dzieciątkowski

Postępy Mikrobiologii - Advancements of Microbiology, Volume 57 , ISSUE 2, 145–155

Research Article | 22-May-2019


in bacterial pathogenesis and the proteins of the Dsb network represent possible targets for new drugs.

Elżbieta Katarzyna Jagusztyn-Krynicka, Anna Marta Banaś, Magdalena Joanna Grzeszczuk

Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 3, 326–334

Original Paper | 07-June-2016

Enzymes Involved in Naproxen Degradation by Planococcus sp. S5

Naproxen is a one of the most popular non-steroidal anti-inflammatory drugs (NSAIDs) entering the environment as a result of high consumption. For this reason, there is an emerging need to recognize mechanisms of its degradation and enzymes engaged in this process. Planococcus sp. S5 is a gram positive strain able to degrade naproxen in monosubstrate culture (27%). However, naproxen is not a suf­ficient growth substrate for this strain. In the presence of benzoate, 4-hydroxybenzoic acid

Danuta Wojcieszyńska, Dorota Domaradzka, Katarzyna Hupert-Kocurek, Urszula Guzik

Polish Journal of Microbiology, Volume 65 , ISSUE 2, 177–182

Case report | 31-March-2016

Successful treatment of epilepsia partialis continua due to Rassmussen encephalitis with perampanel

Background. Epilepsia partialis continua (EPC) is a difficult to treat condition, which tends to be refractory to antiepileptic drugs (AEDs). We previously published two other treatment episodes of EPC due to stroke and vascular dementia with a possible effect of perampanel (PER). Aim. With the publication of a third treatment episode of EPC terminated by the administration of PER we would like to suggest that PER may be an effective treatment option in this condition. Material and Methods. We

Katja Göde, Annette Grossmann, Johannes Rösche

Journal of Epileptology, Volume 24 , ISSUE 1, 67–70

Case report | 14-November-2014

Ictal Forced Repetitive Swearing in Frontal Lobe Epilepsy: Case report and review of the literature

Introduction. Dominant presentation of ictal forced repetitive swearing has been rarely addressed and could be misdiagnosed. Case report. We report a 45-year-old man with a long history of right frontal lobe epilepsy (FLE) who developed forced repetitive swearing during hypermotor seizures. His seizures were refractory to different antiepileptic drugs (AEDs). Scalp video-EEG telemetry suggested a right frontal epileptic focus. Magnetic resonance imaging (MRI) suggested focal cortical dysplasia

Marjan Dolatshahi, Alexei Yankovsky

Journal of Epileptology, Volume 22 , ISSUE 2, 113–119

Research Article | 21-May-2019


high importance due to the increasing usage of arsenic-based drugs in the treatment of certain types of cancer and diseases caused by protozoan parasites as well as for the development of bio- and phytoremediation strategies for metalloid-polluted areas.

Seweryn Mucha, Mateusz Berezowski, Katarzyna Markowska

Postępy Mikrobiologii - Advancements of Microbiology, Volume 56 , ISSUE 1, 88–99

Article | 24-August-2017


For various reasons individuals in a sample survey may prefer not to confide to the interviewer the correct answers to certain potentially sensitive questions such as the illegal use of drugs, illegal earning, or incidence of acts of domestic violence, etc. In such cases the individuals may elect not to reply at all or to reply with incorrect answers. The resulting evasive answer bias is ordinarily difficult to assess. The use of a randomized response method for estimating the proportion of

Kajal Dihidar, Manjima Bhattacharya

Statistics in Transition New Series, Volume 18 , ISSUE 2, 193–210

Mini Review | 04-September-2018

Secondary Metabolites of Actinomycetes and their Antibacterial, Antifungal and Antiviral Properties

The growing resistance of microorganisms towards antibiotics has become a serious global problem. Therapeutics with novel chemical scaffolds and/or mechanisms of action are urgently needed to combat infections caused by multidrug resistant pathogens, including bacteria, fungi and viruses. Development of novel antimicrobial agents is still highly dependent on the discovery of new natural products. At present, most antimicrobial drugs used in medicine are of natural origin. Among the natural


Polish Journal of Microbiology, Volume 67 , ISSUE 3, 259–272

Review Paper | 07-June-2016

Depression and anxiety in people with epilepsy: Why should we identify?

drugs, poor surgical outcome, and eventually, poor quality of life. Furthermore, depression and anxiety were closely associated with perceived stigma, obsessive-compulsive symptom, aggression, fatigue, and perceived stress. Conclusions. Clinicians who take care of PWE in a busy clinical setting should identify their psychiatric problems by brief screening tools and treat them instantly to minimize their negative impacts.

Sung-Pa Park

Journal of Epileptology, Volume 24 , ISSUE 1, 57–62

Original Paper | 10-June-2013

Detection of SCN1A mutations in patients with severe myoclonic epilepsy in infancy by custom resequence array

Introduction. Very few epilepsy phenotypes have been associated with causative genes; nevertheless, it is becoming possible, for some epilepsy phenotypes, to predict the most efficacious anti-epileptic drugs for patients based on their genetic makeup. The development of individualized medicine based on genetic information and the genetic diagnosis of epilepsy are expected to greatly improve the diagnosis and treatment of epilepsy. Here, we developed a DNA array (resequencing array) for the

Takayuki Sugawara, Shuichi Yoshida, Naoko Onodera, Kazumaru Wada, Shinichi Hirose, Sunao Kaneko

Journal of Epileptology, Volume 21 , ISSUE 1, 5–13

research-article | 06-April-2020

Neuroprotective effect of poly(lactic-co-glycolic acid) nanoparticle-bound brain-derived neurotrophic factor in a permanent middle cerebral artery occlusion model of ischemia in rats

Siti Norsyafika Kamarudin, Igor Iezhitsa, Minaketan Tripathy, Renad Alyautdin, Nafeeza Mohd Ismail

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 1–18

review-paper | 23-March-2020

Pharmacological and non-pharmacological approaches to life threatening conditions in epilepsy

patients were proposed by Jones et al. (2014) in the In-Hospital Emergency Drug Management of Convulsive SE in Adults. The first treatment step in the event of SE is administering benzodiazepines for longer than five minutes. The first-choice drugs at this stage are lorazepam (IV), diazepam (IV) or clonazepam (IV). If IV administration is not possible or difficult, then buccal midazolam may be given (alternatively – injection through a buccal route or intramuscular injection). If the above methods are

Barbara Błaszczyk, Aleksandra Walczak, Natalia Ścirka, Agnieszka Konarzewska, Barbara Miziak, Stanisław J. Czuczwar

Journal of Epileptology, Volume 28 , 43–54

Case report | 11-March-2014

Successful treatment with adjunctive lacosamide in a patient with long term “drug resistant” focal epilepsy

Introduction. A significant number of patients suffering from epilepsy prove to be resistant to antiepileptic drugs (AEDs). Recent studies, however, suggest that 10–20% of seemingly drug resistant patients may still become seizure-free under the influence of subsequent dosage modifications. Case report. We report on a young man with cryptogenic focal epilepsy. He had his first seizure at the age of fifteen. His seizure frequency was decreased during the following 11 years. However

Walter Fröscher, Alois Rauber

Journal of Epileptology, Volume 22 , ISSUE 1, 51–55

original-paper | 06-April-2020

Prevalence of Multi-Drug Resistant Mycobacterium Tuberculosis in Khyber Pakhtunkhwa – A High Tuberculosis Endemic Area of Pakistan

–34 years was more likely infected with TB (40%) when compared to other groups (Table I). The susceptibility testing towards the first-line drugs as rifampicin, isoniazid, ethambutol, streptomycin, and pyrazinamide was performed on 1969 culture-positive isolates. Table I Association of TB with gender, different age groups and treatment history, p-value of < 0.05 shows a statistical significance. Character TB Suspects Positive cases p-value Gender Male 3189 947 (29%) χ (3) = 68.2


Polish Journal of Microbiology, Volume 69 , ISSUE 2, 133–137

mini-review | 05-December-2019

Antibiotic Resistance Among Uropathogenic Escherichia coli

catalyzed by glutathione transferase (FosA), L-cysteine thiol transferase (Fos B) or fosfomycin-specific epoxide hydrolase (FosX) (Rigsby et al. 2005). Nitrofurantoin is recommended for the treatment of uncomplicated cystitis and, currently, the resistance of UPEC to nitrofurantoin is very low. Resistance to nitrofurantoin did not evolve as fast as to other drugs because of this antimicrobial acts at multiple targets in the bacterial cell (Veeraraghavan and Shakti 2015). Sandegren et al. (2008


Polish Journal of Microbiology, Volume 68 , ISSUE 4, 403–415

original-paper | 05-December-2019

Diversity, Virulence Factors, and Antifungal Susceptibility Patterns of Pathogenic and Opportunistic Yeast Species in Rock Pigeon (Columba livia) Fecal Droppings in Western Saudi Arabia

zones. A diameter of ≥ 15 mm for nystatin and ≥ 20 mm for the three antifungal agents was considered as susceptible. Susceptibility breakpoints of antifungal drugs used in our study are not species related (CLSI 2008). C. albicans ATCC 90028 was used as control. Results Yeast diversity in pigeon feces. A total of 46 presumptive yeast isolates representing nine different genera, were recovered from pigeon fecal samples collected within the city of Makkah. Table I consolidates the phenotypic


Polish Journal of Microbiology, Volume 68 , ISSUE 4, 493–504

Editorial | 31-March-2017

Rheumatoid arthritis: what do MRI and ultrasound show

disease management, the emergence of new biologic therapies and better utilization of conventional disease-modifying antirheumatic drugs. Prompt diagnosis and appropriate therapy have been recognized as essential for improving clinical outcomes in patients with early rheumatoid arthritis. Despite the potential of ultrasonography and magnetic resonance imaging to visualize all tissues typically involved in the pathogenesis of rheumatoid arthritis, the diagnosis of early disease remains difficult due to

Iwona Sudoł-Szopińska, Lennart Jans, James Teh

Journal of Ultrasonography, Volume 17 , ISSUE 68, 5–16

Research paper | 04-May-2018

Antimuscarinic-induced convulsions in fasted mice after food intake: no evidence of spontaneous seizures, behavioral changes or neuronal damage

Prolonged or repeated seizures have been shown to cause spontaneous recurrent seizures, increased anxiety-related behavior, locomotor hyperactivity, impaired functions of learning and memory, and neuronal damage in the hippocampus and other brain regions in animals. Mice and rats treated with antimuscarinic drugs after fasting for two days or less develop convulsions after being allowed to eat ad libitum. To address whether such behavioral and neuroanatomic changes occur following these

Nurhan Enginar, Asiye Nurten, Aslı Zengin Türkmen, Gül İpek Gündoğan, Zeynep Güneş Özünal

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 4, 373–381

Original Paper | 02-April-2015

The ILAE definition of drug resistant epilepsy and its clinical applicability compared with “older” established definitions

course of disease were extracted from patients' charts. Drug resistant epilepsy was classified according to four definitions and the time until fulfillment of criteria compared. Results. Mean time to fulfillment of criteria of drug resistant epilepsy ranged from 11.8 (standard deviation (SD) 9.8) to 15.6 years (SD 11.3). Time to drug resistance was significantly longer applying the only definition, requiring failure of three antiepileptic drugs (AEDs) (Canada definition), whereas time to

Alexandra Rohracher, Judith Dobesberger, Claudia A. Granbichler, Julia Höfler, Giorgi Kuchukhidze, Martin Ortler, Iris Unterberger, Gerald Walser, Aljoscha Thomschewski, Eugen Trinka

Journal of Epileptology, Volume 23 , ISSUE 1, 39–44

review-article | 05-September-2019

Cannabinoids in the treatment of epilepsy – an updated review

INTRODUCTION Epilepsy is one of the most common disorders of the nervous system. It is a health problem as well as a social and economic one. Epilepsy affects over 65 million people worldwide (CDC, 2012). Patients who suffer from seizures in spite of the administration of two subsequent, appropriately-selected antiepileptic drugs (AEDs) that are well applied and tolerated, are diagnosed with refractory epilepsy (Kwan et al., 2010). It is estimated that 30% of people with epilepsy continue to

Marcin Kopka

Journal of Epileptology, Volume 27 , 35–42

research-article | 06-April-2020

Local field potential power spectra and locomotor activity following treatment with pseudoephedrine in mice

al., 2017), indicating that drugs of abuse or addiction modulate movement control, either directly or indirectly through the activation of the basal ganglia. PSE also increases Fos-like activity, both in the nucleus accumbens and the striatum, which are the brain areas that are essential for reinforcing effects and locomotor functions, respectively (Kumarnsit et al., 1999), indicating that PSE has CNS effects on the basal ganglia at the cellular level. Therefore, it is important to determine

Nusaib Sa-ih, Chayaporn Reakkamnuan, Nifareeda Samerphob, Dania Cheaha, Saree Niyomdecha, Ekkasit Kumarnsit

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 19–31

Article | 26-October-2020

Frequency of thrombocytopenia associated with gentamicin therapy

Many drugs, including antibiotics such as gentamicin, have been associated with the development of a drug-induced thrombocytopenia. Serologic methods for detection of drug-dependent plateIet antibod­ies (DDPAs) are not routinely performed, and the incidence of such antibody-mediated thrombocytopenia is not known. As we routinely perform solid-phase red cell adherence assays for the detection of DDPAs, a study was designed to determine the incidence of gentam­icin-associated platelet

Miriam Fogg Leach, James P. AuBuchon

Immunohematology, Volume 15 , ISSUE 4, 167–170

review-paper | 04-April-2020

Treatment with lacosamide or levetiracetam in patients with renal replacement therapy. What is really known?

approval from the FDA in 1999. It is not protein bound. 66% of the dose is eliminated unchanged and 27% is excreted in urine as an inactive metabolite within 48 hours. It shows very few drug–drug interactions as well (Patsalos, 2004). Therefore, both orally and intravenously applicable drugs are commonly used in those critically ill patients, who need antiepileptic drugs (AEDs) in addition to several other medications. A therapeutic range is recommended for LCM of 5 mg/l–10 mg/l and for LEV of 12 mg/l

Maya Cuhls, Julian Bösel, Johannes Rösche

Journal of Epileptology, Volume 28 , 55–58

Case report | 05-June-2017

The diagnostic dilemma of non-convulsive status epilepticus in sporadic Creutzfeldt-Jakob disease

lateralized epileptiform discharges and NCSE was considered. Discussion. The presented case illustrates the dilemma in the differential diagnosis of sCJD and (symptomatic) NCSE in the light of the recently published new Salzburg consensus criteria and unified EEG terminology. Concerning these criteria, the patient showed after an initial generalized seizure and substantial clinical improvement after administration of antiepileptic drugs, persisting epileptic discharges and only subtle clinical ictal

Matthias Wittstock, Uwe Walter, Daniela Schirrmeister, Kyrylo Kurtieiev, Jan Klinke, Annette Grossmann, Johannes Rösche

Journal of Epileptology, Volume 25 , ISSUE 1-2, 53–58

Article | 30-November-2018


reaction in response to an infection [32, 43, 59, 89, 96]. Some researchers find it unlikely that immunoglobulin therapy would be effective in the cases of severe disease caused by HPeV-3 due to low seroprevalence. Higher IVIG efficacy was observed in HPeV-1 infections than in other types [10, 27, 79]. So far, the effectiveness of drugs used to treat enterovirus infections

Arleta Krzysztoszek, Magdalena Wieczorek

Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 3, 301–315

research-article | 15-October-2020

RhoA/Rock2/Limk1/cofilin1 pathway is involved in attenuation of neuronal dendritic spine loss by paeonol in the frontal cortex of D-galactose and aluminum-induced Alzheimer’s disease-like rat model

drugs in recent years, including the β secretase inhibitor verubecestat (Egan et al., 2018) and the anti-Aβ drugs semagacestat (Doody et al., 2013), bapineuzumab (Vandenberghe et al., 2016) and solanezumab (Neurology, 2017), it is even more important to explore new targets and drugs. In China, polyphenolic Chinese herbal medicine has been used for thousands of years in clinical application, and no toxic effects have been reported (Zhang et al., 2019). Polyphenols are usually easily absorbed by the

Fei Han, Hui Xu, Jun-Xian Shen, Chuan Pan, Zong-Hao Yu, Jing-Jing Chen, Xiu-Ling Zhu, Ya-Fei Cai, Ya-Ping Lu

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 3, 225–244

Research Article | 30-November-2013

Determinants of Binge Drinking among Adolescents in Denmark

Binge drinking is a relatively common behavior among adolescents in Denmark. The aim of this study is to assess whether peer alcohol drinking, mothers’ and fathers’ attitudes toward alcohol drinking, and the adolescents’ own financial situations (e.g., the presence of pocket money) predict binge drinking among adolescents in Denmark.This study is based on the Danish data from the European School Survey Project on Alcohol and Other Drugs, which took place in 2011. This cross-sectional survey

Maria Pedersen, Per Kragh Andersen, Svend Sabroe

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 2 , ISSUE 3, 135–142

Research Article | 30-November-2015

The Growing Trend of Prescribing Antipsychotics for Young People in Finland, 2000 to 2010

According to previous reports from many countries (e.g., the United States, Germany, the United Kingdom), the use of antipsychotic drugs has increased among young people. Antipsychotics have also increasingly been prescribed for non-psychotic disorders.The purpose of this study was to estimate the rate at which antipsychotics were prescribed for young people in the age groups of 10 to 14 years, 15 to 19 years, and 20 to 24 years in Finland in the years 2000, 2005, and 2010.This was a nationwide

Kirsi-Maria Haapasalo-Pesu, Max Karukivi, Simo Saarijärvi

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 4 , ISSUE 1, 31–35

Research paper | 06-February-2018

Effect of combined administration of aripiprazole and fluoxetine on cognitive functions in female rats exposed to ethyl alcohol

effect upon chronic administration may be due to tolerance to memory improvement developing upon combined administration of ARI+FLU. It can be concluded that ARI (1.5 mg/kg), FLU (5 mg/kg), and combined administration of these drugs improves spatial memory in CEt.

Krzysztof Kus, Piotr Ratajczak, Natasza Czaja, Tomasz Zaprutko, Elżbieta Nowakowska

Acta Neurobiologiae Experimentalis, Volume 77 , ISSUE 1, 86–93

Review Paper | 30-September-2016

The epileptic multifactorial patient’s burden. Review of the topic

. Generalized tonic-clonic seizures and refractory epilepsy are the most important factors burdening PWE’s, resulting in increased injuries and mortality, including Sudden Unexpected Death in Epilepsy (SUDEP). The need of chronic intake of antiepileptic drugs (AEDs) and of epilepsy surgery are also important with regards to potential for side effects, drug interactions, and different surgery risks. PWE harbour more medical and psychiatric comorbidities than the general population and results in a

José Pimentel

Journal of Epileptology, Volume 24 , ISSUE 2, 167–172

case-report | 21-November-2019

Glucose transporter type 1 deficiency syndrome (GLUT1-DS) – delayed diagnosis and treatment. A case report

administered 300 mg per day. The second and the last epileptic seizure was observed when she was six. She had been taking different antiepileptic drugs for the next sixteen years, because of sudden involuntary movements and sudden collapses which were diagnosed as epileptic seizures. In spite of many treatment modifications no clinical effect was noted. In the following years, the incidence of muscle fatigability, balance disturbances and anxiety lasting up to one hour, were often observed. The patient was

Piotr Bogucki, Ewa Nagańska, Marta Jurek, Dorota Hoffman-Zacharska, Anna Kutkowska-Kaźmierczak, Ewa Obersztyn, Urszula Fiszer

Journal of Epileptology, Volume 27 , 49–54

Research Article | 13-September-2016

Behavioral Weight Loss Treatment for Youth Treated With Antipsychotic Medications

Background:Youth who are being treated with antipsychotic medications are at increased risk for the development of obesity and type 2 diabetes. Behavioral weight loss treatments show promise for reducing obesity and diabetes risk among adults treated with these drugs, but such treatments have not previously been studied in youth.Objective:We describe a rationale for behavioral weight loss intervention for high-weight youth being treated with antipsychotic medications. We report behavioral

Ginger E. Nicol, Rachel P Kolko, Monica Mills, Thrudur Gunnarsdottir, Michael D. Yingling, Julia A. Schweiger, Eric J. Lenze, John W. Newcomer, Denise Wilfley

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 4 , ISSUE 2, 96–104

research-article | 30-November-2020

Salvia divinorum increases alcohol intake and tonic immobility whilst decreasing food intake in Wistar rats

, there is increasing evidence that links the action of the endogenous opioid neuropeptide, dynorphin, in modulating mood and increasing the reward effects of abused drugs (Bruchas et al., 2010). It has been hypothesized that the kappa-opioid system (KOP) largely modulates drug consumption, in order of the number of publications: cocaine, alcohol, opioids and nicotine and cannabinoids to a lesser extent (Wee and Koob, 2010). Previous studies have provided evidence of an anti-addictive effect resulting

Priscila Vázquez-León, Ulises Arenas-Martínez, Dafne Córdova-Maqueda, Tomás Fregoso-Aguilar, Eduardo Ramírez-San Juan, Abraham Miranda-Páez

Acta Neurobiologiae Experimentalis, Volume 81 , ISSUE 1, 34–42

Review Paper | 19-January-2015

Neurostimulation, neuromodulation, and the treatment of epilepsies

magnetic stimulation (rTMS). Are these devices and techniques simply another treatment option that can be offered to patients with epilepsy or do they offer specific advantages when compared to the standard antiepileptic drugs (AEDs)? Aim. The aim of this review is to present the neurostimulation and neuromodulation devices and techniques that are now in use, or at least available for testing and to discuss the science behind them, their applications, efficacy, potential risks vs. benefits and, above

Lauren B. Bolden, Sandipan Pati, Jerzy P. Szaflarski

Journal of Epileptology, Volume 23 , ISSUE 1, 45–59

Review Paper | 07-April-2017

Genetic epilepsies. remarks on the proposed “organization of the Epilepsies”

include into genetic testing genes responsible for the side effects of AEDs. In addition, for some epilepsy phenotypes it has became possible to predict the most efficacious antiepileptic drugs for patients based on their genetic makeup. Thus, the development of individualized medicine is expected to greatly improve the management of epilepsy patients.

Heinz Gregor Wieser

Journal of Epileptology, Volume 22 , ISSUE 1, 11–23

research-article | 27-August-2018

Ketogenic diet in epilepsy: an updated review

more likely to cause seizure aggravation compared to other medicines (Kossoff et al., 2009a; McArtney et al., 2017). The influence of the KD on the absorption of AEDs may be significant due to the nausea and vomiting often observed at the beginning, as well as due to the slowed gastric emptying induced by the diet. These conditions may lead to a decreased concentration of AEDs and in consequence to a transient exacerbation of seizures. Sometimes during KD implementation, the concentration of drugs

Magdalena Dudzińska

Journal of Epileptology, Volume 26 , ISSUE 1-2, 27–47

review-paper | 11-February-2020

Clinical characteristics of forced normalization and alternative psychosis with special consideration of the new anticonvulsants

episode was one month (3 days – several years, n = 35 patients); obviously the duration is very different. An AP/FN episode may be terminated spontaneously, by spontaneous seizures, by seizures induced by reduction of the anticonvulsant medication or by antipsychotic drugs (see below, treatment). The development of a chronic psychotic state is considered to be a rare event. There are, however, some patients who alternate repeatedly between periods with seizures and seizure-free periods with mental

Walter Fröscher, Volker Faust, Tilman Steinert

Journal of Epileptology, Volume 28 , 35–41

Original Paper | 15-January-2018

Adenosine receptor agonists differentially affect the anticonvulsant action of carbamazepine and valproate against maximal electroshock test-induced seizures in mice

Background. Adenosine is regarded as an endogenous anticonvulsant and its agonists have been proved to affect the anticonvulsant activity of a number of antiepileptic drugs (AEDs) in animal models of seizures. Aim. To evaluate effects of adenosine agonists on carbamazepine (CBZ) and valproate (VPA) in mouse model of generalized tonic-clonic convulsions. Methods. The following adenosine receptor agonists were used: A 1 – cyclohexyladenosine, A2A – CGS 21 680, A3 – N6-benzyl

Mirosław Jasiński, Magdalena Chrościńska-Krawczyk, Stanisław J. Czuczwar

Journal of Epileptology, Volume 25 , ISSUE 1-2, 21–29

Original Paper | 03-April-2013

Neurobiological and clinical predictors of remission and antiepileptic treatment efficacy in partial epilepsies

were the worst combinations for the remission length and TLE • Fe • Lh • LF for the seizures reduction. Conclusions. The current study revealed the significance of combinations of some neurobiological and clinical variables in prediction of therapeutic remission and percent of seizures reduction irrespective of used antiepileptic drugs. These results may be used so as to aid patient selection before drug treatment in order to form the homogenous groups of persons.

Vladimir V. Kalinin, Anna A. Zemlyanaya, Elena V. Zheleznova, Lyudmila V. Sokolova

Journal of Epileptology, Volume 21 , ISSUE 1, 15–25

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