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Article | 10-June-2019

CELL BANKS PREPARATION IN BIOPHARMACEUTICALS PRODUCTION

biopharmaceuticals, which are recombinant proteins with therapeutic properties. This made the mass production of safe and effective medications possible. Currently, many diseases are treated with biopharmaceuticals produced by the DNA recombination technology [7, 65]. Manufacturing biopharmaceuticals is strictly regulated by international guidelines defining the proper conduct during production process. The entire technological process, such as: selection of the expression system, cell culture, creation of cell

Agnieszka Sobolewska-Ruta, Piotr Zaleski

Postępy Mikrobiologii - Advancements of Microbiology, Volume 58 , ISSUE 1, 87–100

original-paper | 03-September-2019

Antifungal Activity and Physicochemical Properties of a Novel Antimicrobial Protein AMP-17 from Musca domestica

, Candida tropicalis, Candida parapsilosis, and C. neoformans. To further understand the physical and chemical properties of AMP-17 protein, the salt, acid-base, and thermal stabilities were also assayed. In addition, cytotoxicity and hemolytic activity of AMP-17 protein were determined, as a prelude to more extensive safety evaluation. Experimental Materials and Methods Materials. AMP-17 protein was obtained from the Guoguo research team. It was produced in a prokaryotic expression system and

LONG-BING YANG, GUO GUO, XIN-YU ZHAO, PEI-PEI SU, PING FU, JIAN PENG, JIANG-FAN XIU, BO-YAN LI

Polish Journal of Microbiology, Volume 68 , ISSUE 3, 383–390

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