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Case report | 15-June-2016

Concomitant treatment with imipenem causes a rapid and extensive decrease in the plasma concentrations of valproic acid

Background. Valproic acid (VPA) is a wide-spectrum antiepileptic drug used both in children and in adults. We describe a clinically important interaction between VPA and imipenem, a carbapenem antimicrobial. Case presentation. Our patient was a 19-year-old man with childhood onset of mental retardation and severe epilepsy. He was hospitalized due to pneumonia. His antiepileptic drugs, including VPA, were administered intravenously. Due to pneumonia, intravenously administered imipenem was

Tapani Keränen, Hanna Kuusisto

Journal of Epileptology, Volume 24 , ISSUE 1, 63–66

Short Communication | 09-March-2018

Evaluation of the Carba NP Test for the Detection of Carbapenemase Activity in Bacteroides Species

We evaluated the usefulness of the Carba NP test for rapid detection of carbapenemase activity in Bacteroides spp. The minimum inhibitory concentration (MIC) for imipenem was determined with gradient test strips, and cfiA gene was investigated by polymerase chain reaction for 27 clinical Bacteroides spp. isolates. Carba NP test was performed according to recommendations of the Clinical and Laboratory Standards Institute. Among three cfiA gene harboring clinical isolates, two imipenem resistant

Isin Akyar, Meltem Ayas, Onur Karatuna, Yesim Besli

Polish Journal of Microbiology, Volume 67 , ISSUE 1, 97–101

original-paper | 17-September-2021

Rapid Detection and Differentiation of KPC and MBL Carbapenemases among Enterobacterales Isolates by a Modified Combined-Disk Test

isolates and 90 third-generation cephalosporin-resistant Enterobacterales (3GCeRE) isolates from the Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital were included. CRE was defined as an isolate non-susceptible to imipenem or meropenem (for the bacteria intrinsically resistant to imipenem, non-susceptible to meropenem other than imipenem is required), with a minimum inhibitory concentration (MIC) ≥ 2 µg/ml, or producing carbapenemase. 3GCeRE was defined as an


Polish Journal of Microbiology, Volume 70 , ISSUE 3, 387–394

Original Paper | 15-March-2016

Effectiveness of Antipseudomonal Antibiotics and Mechanisms of Multidrug Resistance in Pseudomonas aeruginosa

susceptibility (100%, n = 86/86) to piperacillin, meropenem, amikacin, and polymyxin B. A single isolate was found to be imipenem resistant (99%, n = 85/86). The possible mechanisms of resistance of P. aeruginosa to imipenem involve active drug efflux pumps, outer membrane impermeability as well as drug inactivating enzymes. These findings demonstrate the fundamental importance of the in vitro susceptibility testing of antibiotics prior to antipseudomonal therapy and highlight the need for a continuous

Mohamed E. El Zowalaty, Béla Gyetvai

Polish Journal of Microbiology, Volume 65 , ISSUE 1, 23–32

original-paper | 09-March-2021

Antibiotic and Disinfectant Resistance in Tap Water Strains – Insight into the Resistance of Environmental Bacteria

-Hinton by swabbing three times, every time turning the plate by 60 degrees. Next, the disks containing the antibiotics (BioMaxima) were placed on plates with inoculated bacteria utilizing a dispenser (BioMaxima). The antibiotics selected for testing included (abbreviation, disk content in μg): ampicillin (AM, 10), aztreonam (ATM, 30), ertapenem (ETP, 10), imipenem (IMP, 10) meropenem (MEM, 10), ofloxacin (OFX, 5), cefotaxime (CTX, 5), cefepime (FEP, 30), doxycycline (DO, 30), oxytetracycline (T, 30


Polish Journal of Microbiology, Volume 70 , ISSUE 1, 57–67

Original Paper | 10-December-2018

Microbiology and Drug Resistance of Pathogens in Patients Hospitalized at the Nephrology Department in the South of Poland

(8.0%) can produce extended-spectrum β-lactamases (ESBL). E. coli was highly sensitive to imipenem (100.0%), gentamicin (91.0%), nitrofurantoin (89.4%), amikacin (88.2%), piperacillin/ tazobactam (87.0%) and cephalosporins (79.7–89.5%). Low sensitivity was found in relation to fluoroquinolones (60.3–70.4%). E. coli was least sensitive to ampicillin (30.2%) and amoxicillin/clavulanic acid (49.9%). We observed a significant fall in susceptibility level to piperacillin/tazobactam (68.4% vs. 88.8%; p


Polish Journal of Microbiology, Volume 67 , ISSUE 4, 517–524

original-paper | 19-March-2021

Clonal Dissemination of KPC-2, VIM-1, OXA-48-Producing Klebsiella pneumoniae ST147 in Katowice, Poland

, ischemic heart disease Amoxicillin/clavulanic acid – Alive 6 70/F REU 09/03/2018 Rectal swab Colonization 26/02-14/03/2018 (17 days) Diabetes, metastatic lung cancer – – Alive 7 78/F REU 09/03/2018 Rectal swab Colonization 27/02-16/03/2018(18 days) Rheumatoid Arthritis (RA), hemorrhagic diathesis, coronary disease, peptic ulcer disease, hypertension, atherosclerosis, gout Imipenem Vancomycin Alive 5 90/F REU 08/03/2018 Rectal swab Colonization 03.03-17.03.2018 (14 days) Atherosclerosis, acute


Polish Journal of Microbiology, Volume 70 , ISSUE 1, 107–116

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