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Article | 10-April-2021

Group O blood donors in Iran: evaluation of isoagglutinin titers and immunoglobulin G subclasses

the fact that some transfusion service providers have a policy against using high-titer plasma components, specifically platelet concentrates, there is still a lack of agreement on the threshold titer value that would lead to an unsafe blood component.6,7 Diet, as well as ethnic and environmental factors, play a contributing role in the level of isoagglutinin titers in different populations; therefore, it is important to determine the frequency of high isoagglutinin titers in each population and

S. Arabi, M. Moghaddam, A.A. Pourfathollah, A. Aghaie, M. Mosaed

Immunohematology, Volume 37 , ISSUE 1, 5–12

Article | 16-February-2021

Quality improvement with platelet additive solution for safer out-of-group platelet transfusions

blood volume during transfusion. If the recipient is a secretor (80% of the population), the soluble A or B blood group substances in the recipient’s plasma can neutralize some anti-A or anti-B isoagglutinins in the donor’s plasma.12,13 This protection becomes ineffective, however, when the recipient is not a secretor or large amounts of anti-A and anti-B are involved.14 In the situation described, a single platelet component with a high isoagglutinin titer can be harmful,8,15–22 and even fatal,8,22

M. Tynuv, W.A. Flegel

Immunohematology, Volume 35 , ISSUE 3, 108–115

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