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Article | 26-October-2020

Naturally-occurring anti-Jka in infant twins

with ficin- or papain-treated RBCs. Monocyte monolayer assays using Jk(a+) RBCs sensitized by either twins' serum were nonreactive (0%). RBCs from both parents typed as Jk(a+b+). Both parents’ antibody detection test results by SPRCA assay were negative. The absence of a history of exposure to allogeneic RBCs or possible passive transfer of maternal or other alloantibody classifies these antibodies as naturally-occurring anti-Jka.

Dawn H. Rumsey, Sandra J. Nance, Mary Rubino, S. Gerald Sandler

Immunohematology, Volume 15 , ISSUE 4, 159–162

Article | 16-October-2019

Clinical and laboratory profile of anti-M

The MNS blood group system was identified by Landsteiner and Levine in 1927.1 Many antibodies in this system may be naturally occurring. The most common of these is anti-M, first described by Wolff and Johnson in 1933.2 The MNS blood group system consists of 49 antigens, of which two allelic pairs (M/N and S/s) are polymorphic in most populations.3 M and N are located on glycophorin A glycoprotein. Glycophorin A is expressed on the surface of mature as well as developing erythrocytes.4 Makroo

D. Basu, S. Basu, M. Reddy, K. Gupta, M. Chandy

Immunohematology, Volume 33 , ISSUE 4, 165–169

Review | 16-October-2019

A brief overview of clinical significance of blood group antibodies

This review was derived from a presentation made on September 2, 2016 for the first Academy Day presented by the Working Party on Immunohematology at the International Society of Blood Transfusion (ISBT) Congress in Dubai. The focus of this review is to provide a brief overview of the clinical significance of blood group antibodies. Blood group antibodies can be naturally occurring (e.g., anti-A and anti-B through exposure to naturally occurring red blood cell [RBC] antigen-like substances) or

Manish J. Gandhi, D. Michael Strong, Barbee I. Whitaker, Evangelia Petrisli

Immunohematology, Volume 34 , ISSUE 1, 4–6

Article | 26-October-2020

Mta: review and case report

Anti-Mta, which recognizes an antigen in the MNS blood group system, was detected during prenatal testing of a para 6, gravida 1 woman with no history of transfusions. Her husband was apparently Mt(a–). Anti-Mta was first reported in 1962 as a naturally occurring antibody directed against a new antigen in the MNS system. The last report in the literature of detection of anti-Mta was in 1972.

Lisa Bakowski, Joanne Kosanke

Immunohematology, Volume 15 , ISSUE 2, 78–79

Case report | 11-March-2020

An unusual case of an acute hemolytic transfusion reaction caused by an autoanti-I

In general, naturally occurring cold autoagglutinins react optimally at low temperatures. We describe a young child who experienced an acute hemolytic transfusion reaction by an unusual autoanti-I. The IgM autoanti-I was detected at 4°C (titer 256) and also reacted at 30°C. This case highlights the potential hazard of transfusing units of blood immediately upon removal from the blood refrigerator, especially into neonates and children of small stature.

Nay Win, Sally Rahman, Philip Gold, Susan Ward

Immunohematology, Volume 27 , ISSUE 3, 101–103

Letter to Editor | 16-October-2019

Letter to the Editor: Clinically significant naturally occurring anti-N and anti-S in a blood donor: a rare finding

Sheetal Malhotra, Gita Negi, Aseem Kumar Tiwari

Immunohematology, Volume 34 , ISSUE 2, 66–68

case-report | 25-June-2021

Anti-A1Leb: a mind boggler

be incompatible, whereas all group O, D+ and A2, D+ blood units were compatible with patient’s serum. Ruling out all donor- and patient-related causes of incompatible crossmatch (both at room temperature and 37°C) with a negative IAT, the diagnosis was narrowed down to a compound antibody reacting against two different antigens. Such a compound antibody was identified as anti-A1Leb, which reacts only in the presence of both A1 and Leb antigens (Table 6). Lewis antibodies are generally naturally

A. Gupta, K. Chaudhary, S. Asati, B. Kakkar

Immunohematology, Volume 37 , ISSUE 2, 69–71

Review | 01-December-2019

An update on the GLOB blood group system and collection

The P blood group antigen of the GLOB system is a glycolipid structure, also known as globoside, on the red blood cells (RBCs) of almost all individuals worldwide. The P antigen is intimately related to the Pk and NOR antigens discussed in the review about the P1PK blood group system. Naturally occurring anti-P is present in the serum of individuals with the rare globosidedeficient phenotypes p, P1k, and P2k and has been implicated in hemolytic transfusion reactions as well as unfavorable

Åsa Hellberg, Julia S. Westman, Martin L. Olsson

Immunohematology, Volume 29 , ISSUE 1, 19–24

Case report | 17-March-2020

Clinical evaluation for lymphoproliferative disease prompted by finding of IgM warm autoanti-IT in two cases

Anti-IT is an unusual specificity originally described as a naturally occurring cold agglutinin. The antibody reacts strongly with cord RBCs, weakly with adult I RBCs, and most weakly with the rare adult i RBCs. IgG anti-IT in patients with hemolytic anemia has been associated with Hodgkin’s lymphoma. Difficulties in blood grouping tests and the presence of a warm reactive agglutinin in samples from two patients with hemolytic anemia led to further serologic studies and the identification

Regina M. Leger, Frederick Lowder, Maria C. Dungo, Weip Chen, Holli M. Mason, George Garratty

Immunohematology, Volume 25 , ISSUE 2, 60–62

Article | 17-February-2021

May the FORS be with you: a system sequel

FORS blood group system has mainly focused on the presence and level of the naturally occurring antibodies seen in the majority of all humans. The question is what the clinical relevance of these antibodies may be. Because most blood centers do not have access to RBCs with the very rare FORS1+ phenotype, different approaches have been used to screen for anti-FORS1 and to estimate its prevalence: Screening with FORS1+ RBCs (only in one study).9 Kodecytes as described by Frame et al.12 have been

A.K. Hult, M.L. Olsson

Immunohematology, Volume 36 , ISSUE 1, 14–18

Review | 17-March-2020

The ABO blood group system revisited: a review and update

The antigens of the ABO system were the first to be recognized as blood groups and actually the first human genetic markers known. Their presence and the realization of naturally occurring antibodies to those antigens lacking from the cells made sense of the erratic failure of blood transfusion hitherto and opened up the possibility of a safe treatment practice in life-threatening blood loss. Although initially apparently simple, the ABO system has come to grow in complexity over the years. The

Jill R. Storry, Martin L. Olsson

Immunohematology, Volume 25 , ISSUE 2, 48–59

Case report | 09-October-2019

Postpartum acute hemolytic transfusion reactions associated with anti-Lea in two pregnancies complicated by preeclampsia

Lewis blood group antibodies, which are mostly naturally occurring and considered clinically insignificant, have rarely been documented as a cause of acute hemolytic transfusion reactions (AHTRs). This report presents two cases of AHTRs caused by anti-Lea occurring in postpartum black females (one group B, one group AB) whose pregnancies were complicated by preeclampsia. Neither anti-Lea was detected by automated solid-phase red cell adherence technology in pre-transfusion testing. Therefore

Marcia Marchese

Immunohematology, Volume 33 , ISSUE 3, 114–118

Review | 09-October-2019

The FORS awakens: review of a blood group system reborn

The presence of the FORS1 antigen on red blood cells was discovered relatively recently, and in 2012, the International Society of Blood Transfusion (ISBT) acknowledged FORS as blood group system number 031. This rare antigen is carried by a glycosphingolipid and formed by elongation of the P antigen. Most people have naturally occurring anti-FORS1 in their plasma. The clinical significance of these antibodies is unknown in the transfusion setting, but they can hemolyze FORS1+ erythrocytes in

Annika K. Hult, Martin L. Olsson

Immunohematology, Volume 33 , ISSUE 2, 64–72

Article | 30-July-2021

Three-dimensional computed tomographic assessment of mandibular muscles in growing subjects with different vertical facial patterns

subjects. This was also more obvious in the maxillary arch. Conclusion: Clinicians should note the likely differences in masseter and medial pterygoid orientation and volume in subjects with different underlying vertical facial patterns and that these differences may, in turn, be related to both facial skeletal width and naturally-occurring transverse dental arch dimensions.

Alwyn Wong, Michael G. Woods, Damien Stella

Australasian Orthodontic Journal, Volume 32 , ISSUE 1, 2–17

Review | 01-December-2019

P1PK: The blood group system that changed its name and expanded

The antigens in the P1PK blood group system are carried on glycosphingolipids. The system currently includes three different antigens, P1, Pk, and NOR. The P1 antigen was disovered in 1927 by Landsteiner and Levine, and Pk and NOR were described in 1951 and 1982, respectively. As in the ABO system, naturally occurring antibodies of the immunoglobulin (Ig) M or IgG class, against the missing carbohydrate structures, can be present in the sera of people lacking the corresponding antigen. Anti-P1

Åsa Hellberg, Julia S. Westman, Britt Thuresson, Martin L. Olsson

Immunohematology, Volume 29 , ISSUE 1, 25–33

research-article | 19-March-2020

Natural occurrence and distribution of entomopathogenic nematodes (Steinernematidae, Heterorhabditidae) in Viti Levu, Fiji Islands

Sumeet Kour, Uma Khurma, Gilianne Brodie, Selcuk Hazir

journal of nematology, Volume 52 , 1–17

Article | 09-November-2020

A modified PCR-RFLP genotyping method demonstrates the presence of the HPA-4b platelet alloantigen in a North American Indian population

the HPA-4 antigen system does not involve a common naturally occurring restriction enzyme site. This paper describes a new genotyping method for HPA-4 (polymerase chain reaction–restriction fragment length polymorphism [PCR-RFLP]) that involves restriction enzyme digestion of PCR-amplified genomic DNA using a modified PCR primer to create an artificial TaqI restriction site that is present in the HPA-4a but not in the HPA-4b DNA sequence. The HPA-4 PCR-RFLP method was validated by testing a

Alexander P. Reiner, Gayle Teramura

Immunohematology, Volume 13 , ISSUE 2, 37–43

Article | 24-July-2017

Gossypium arboreum Accessions Resistant to Rotylenchulus reniformis

In the southeastern United States, reniform nematode (Rotylenchulus reniformis) is a serious pest of upland cotton (Gossypium hirsutum), a species which has no naturally occurring resistance against this nematode. To identify sources of reniform nematode resistance in species closely related to upland cotton, 222 G. arboreum accessions from the U.S. germplasm collection were evaluated in repeated growth chamber experiments. In initial screenings, root infection was measured 4 wks

SALLIANA R. STETINA, JOHN E. ERPELDING

Journal of Nematology, Volume 48 , ISSUE 4, 223–230

Report | 01-December-2019

Seroprevalence of unexpected red blood cell antibodies among pregnant women in Uganda

evidence of agglutination. Nine of the 21 samples demonstrated the presence of clinically significant RBC antibodies with anti-S being the most common, 8 samples demonstrated the presence of benign or naturally occurring antibodies, and 4 had only inconclusive reactivity. This study revealed a relatively high frequency of D and a low frequency of demonstrable clinically significant alloantibodies that may cause hemolytic disease of the newborn or hemolytic transfusion reactions among pregnant women in

Kristina Eipl, Clemensia Nakabiito, Kabali Bwogi, Mahnaz Motevalli, Angela Roots, Lorraine Blagg, J. Brooks Jackson

Immunohematology, Volume 28 , ISSUE 4, 115–117

Case report | 01-December-2019

Anti-Ge2: further evidence for lack of clinical significance

Anti-Ge2 may be immune or naturally occurring, and it reacts with an antigen on glycophorin D. Ge2 is encoded by a gene, GYPC, which is located on the long arm of chromosome 2. Anti-Ge2 is usually an immunoglobulin G (IgG) antibody. In the available literature, we have not been able to find any reported cases of proven acute hemolytic transfusion reactions caused by anti-Ge2. We present the case of a 67-year-old man with metastatic pancreatic carcinoma who had symptomatic anemia and a

Deepthi Karunasiri, Frederick Lowder, Nora Ostrzega, Dennis Goldfinger

Immunohematology, Volume 30 , ISSUE 4, 156–157

research-article | 30-November-2020

PHYTOTHERAPY IN THE PREVENTION AND SUPPORT OF TREATMENT OF HELICOBACTER PYLORI INFECTIONS

Małgorzata Siwińska, Martyna Mucha, Agata Pyrzanowska, Michał Szlaur

Advancements of Microbiology – Postepy Mikrobiologii, Volume 60 , ISSUE 2, 161–172

research-article | 21-October-2020

Optimizing for taxonomic coverage: a comparison of methods to recover mesofauna from soil

-Herrera et al., 2015, 2019). For example, surveys of naturally occurring communities of entomopathogenic nematodes and some of their natural enemies have identified soil properties such as pH (Hara et al., 1991; Campos-Herrera et al., 2013a), salinity (Hara et al., 1991; Nielsen et al., 2011), texture and moisture (Campos-Herrera et al., 2013b) that potentially modulate EPN populations directly, or indirectly by affecting their hosts (Gazit et al., 2000) or natural enemies (Duncan et al., 2013; Campos

Alexandros Dritsoulas, Larry W. Duncan

Journal of Nematology, Volume 52 , 1–9

Research Article | 30-November-2012

Modeling Patterns of Negative Life Events and Mental Health in Faroese Adolescents

The objective of this study was to identify naturally occurring typologies of Faroese adolescents on the basis of their exposure to traumatic and negative life events. It was hypothesized that underlying typologies of trauma and negative life events would be uncovered. Furthermore, it was hypothesized that males would be overrepresented in classes characterized by the endorsement of a wide range of trauma and negative life events. On the basis of prior research, it was also hypothesized that

Tóra Petersen, Cherie Armour, Ask Elklit

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Volume 1 , ISSUE 2, 63–71

Article | 21-July-2017

Evaluation of Steam and Soil Solarization for Meloidogyne arenaria Control in Florida Floriculture Crops

Steam and soil solarization were investigated for control of the root-knot nematode Meloidogyne arenaria in 2 yr of field trials on a commercial flower farm in Florida. The objective was to determine if preplant steam treatments in combination with solarization, or solarization alone effectively controlled nematodes compared to methyl bromide (MeBr). Trials were conducted in a field with naturally occurring populations of M. arenaria. Treatments were solarization alone, steam treatment after

NANCY KOKALIS-BURELLE, ERIN N. ROSSKOPF, DAVID M. BUTLER, STEVEN A. FENNIMORE, JOHN HOLZINGER

Journal of Nematology, Volume 48 , ISSUE 3, 183–192

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