research-article | 22-November-2018
Valproic acid (2-propylpentanoic acid) is a branched-short-chain fatty acid derived from valeric acid which is extracted from Valeriana officinalis (Fan et al., 2016; Tomson et al., 2016). Valproic acid is commonly used for the treatment of epilepsy, psychiatric disorders such as bipolar disorder and anxiety and prophylaxis of a migraine (Ghodke-Puranik et al., 2013; Terbach and Williams, 2009; Tseng et al., 2017).
Valproic acid is well absorbed and has a very high ability to bind
Wardah Rahmatul Islamiyah
Journal of Epileptology, Volume 26 , ISSUE 1-2, 49–54
Case report | 15-June-2016
Background. Valproic acid (VPA) is a wide-spectrum antiepileptic drug used both in children and in adults. We describe a clinically important interaction between VPA and imipenem, a carbapenem antimicrobial. Case presentation. Our patient was a 19-year-old man with childhood onset of mental retardation and severe epilepsy. He was hospitalized due to pneumonia. His antiepileptic drugs, including VPA, were administered intravenously. Due to pneumonia, intravenously administered imipenem was
Journal of Epileptology, Volume 24 , ISSUE 1, 63–66
research-article | 06-April-2020
pigment cells, and tissues, including bone, cartilage, and the connective tissue on the face and ventral neck (Sieber-Blum et al., 2004). EPI-NCSCs can be obtained through a minimally invasive procedure and can be expanded into a pure population of cells through cell culture techniques. Although these stem cells present strong migration abilities, they are not tumorigenic and can be used as autografts (Sieber-Blum and Hu, 2008).
Valproic acid (VPA) is a well-known drug used to treat a wide range of
Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 38–46
Letter to Editor | 07-September-2016
Journal of Epileptology, Volume 24 , ISSUE 2, 85–86
research-article | 27-March-2019
, these recommendations were reviewed by the appointed, extended group of Polish experts from the Board of the PSE, the Foundation of Epileptology and the National Consultant in Neurology. As a result of joint work and reaching a consensus, an updated version of these recommendations has been prepared. This update primarily concerns information on the safety of valproic acid (VPA) in women of childbearing potential and modified recommendations for the treatment of monotherapy in patients with newly
Journal of Epileptology, Volume 27 , 9–16
Review Paper | 10-December-2015
authors describe A_-induced hyperexcitability of hippocampal nerve cells as the cause of cognitive deficits, the connection of such activity with an increased risk of seizures and epilepsy in patients with MCI/AD, and finally the efficacy of AEDs: valproic acid (VPA), phenytoin (PHT), topiramate (TPM), lamotrigine (LTG), ethosuximide (ESM) and levetiracetam (LEV) in the prevention of cognitive impairment in experimental models and patients with MCI/AD. Conclusions. The majority of the studied AEDs
Journal of Epileptology, Volume 23 , ISSUE 2, 139–147
review-paper | 11-February-2020
1987 to 2017, we reported 66 published AP/FN cases (Fröscher and Steinert, 2019). Only 15 out of 66 patients were treated with monotherapy, reducing the accountability to single components. The most commonly triggering anticonvulsants were (with decreasing frequency): vigabatrin, levetiracetam, ethosuximide, carbamazepine, valproic acid.
Once to three times the following anticonvulsants were described as triggers: lamotrigine, phenytoin, topiramate, zonisamide, ACTH (corticotropin), clonazepam
Journal of Epileptology, Volume 28 , 35–41