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research-article | 22-November-2018

The potential mechanisms of effect of valproic acid on lipid profiles: an updated review

INTRODUCTION Valproic acid (2-propylpentanoic acid) is a branched-short-chain fatty acid derived from valeric acid which is extracted from Valeriana officinalis (Fan et al., 2016; Tomson et al., 2016). Valproic acid is commonly used for the treatment of epilepsy, psychiatric disorders such as bipolar disorder and anxiety and prophylaxis of a migraine (Ghodke-Puranik et al., 2013; Terbach and Williams, 2009; Tseng et al., 2017). Valproic acid is well absorbed and has a very high ability to bind

Santoso Jaeri, Wardah Rahmatul Islamiyah

Journal of Epileptology, Volume 26 , ISSUE 1-2, 49–54

Case report | 15-June-2016

Concomitant treatment with imipenem causes a rapid and extensive decrease in the plasma concentrations of valproic acid

Background. Valproic acid (VPA) is a wide-spectrum antiepileptic drug used both in children and in adults. We describe a clinically important interaction between VPA and imipenem, a carbapenem antimicrobial. Case presentation. Our patient was a 19-year-old man with childhood onset of mental retardation and severe epilepsy. He was hospitalized due to pneumonia. His antiepileptic drugs, including VPA, were administered intravenously. Due to pneumonia, intravenously administered imipenem was

Tapani Keränen, Hanna Kuusisto

Journal of Epileptology, Volume 24 , ISSUE 1, 63–66

research-article | 06-April-2020

Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells

pigment cells, and tissues, including bone, cartilage, and the connective tissue on the face and ventral neck (Sieber-Blum et al., 2004). EPI-NCSCs can be obtained through a minimally invasive procedure and can be expanded into a pure population of cells through cell culture techniques. Although these stem cells present strong migration abilities, they are not tumorigenic and can be used as autografts (Sieber-Blum and Hu, 2008). Valproic acid (VPA) is a well-known drug used to treat a wide range of

Zahra Baharvand, Mohammad Nabiuni, Mohammad Tahmaseb, Elaheh Amini, Sareh Pandamooz

Acta Neurobiologiae Experimentalis, Volume 80 , ISSUE 1, 38–46

Letter to Editor | 07-September-2016

The role of the hepatic metabolisation for the interaction between valproic acid and carbapenem antibiotics

Johannes Rösche

Journal of Epileptology, Volume 24 , ISSUE 2, 85–86

research-article | 27-March-2019

Recommendations of the Polish Society of Epileptology for the treatment of epileptic seizure in adult patients in Poland: an update

, these recommendations were reviewed by the appointed, extended group of Polish experts from the Board of the PSE, the Foundation of Epileptology and the National Consultant in Neurology. As a result of joint work and reaching a consensus, an updated version of these recommendations has been prepared. This update primarily concerns information on the safety of valproic acid (VPA) in women of childbearing potential and modified recommendations for the treatment of monotherapy in patients with newly

Joanna Jędrzejczak, Beata Majkowska-Zwolińska, Danuta Ryglewicz, Ewa Nagańska, Maria Mazurkiewicz-Bełdzińska

Journal of Epileptology, Volume 27 , 9–16

Review Paper | 10-December-2015

Antiepileptic drugs as a new therapeutic concept for the prevention of cognitive impairment and Alzheimer’s disease. Recent advances

authors describe A_-induced hyperexcitability of hippocampal nerve cells as the cause of cognitive deficits, the connection of such activity with an increased risk of seizures and epilepsy in patients with MCI/AD, and finally the efficacy of AEDs: valproic acid (VPA), phenytoin (PHT), topiramate (TPM), lamotrigine (LTG), ethosuximide (ESM) and levetiracetam (LEV) in the prevention of cognitive impairment in experimental models and patients with MCI/AD. Conclusions. The majority of the studied AEDs

Krzysztof Sendrowski, Wojciech Sobaniec

Journal of Epileptology, Volume 23 , ISSUE 2, 139–147

review-paper | 11-February-2020

Clinical characteristics of forced normalization and alternative psychosis with special consideration of the new anticonvulsants

1987 to 2017, we reported 66 published AP/FN cases (Fröscher and Steinert, 2019). Only 15 out of 66 patients were treated with monotherapy, reducing the accountability to single components. The most commonly triggering anticonvulsants were (with decreasing frequency): vigabatrin, levetiracetam, ethosuximide, carbamazepine, valproic acid. Once to three times the following anticonvulsants were described as triggers: lamotrigine, phenytoin, topiramate, zonisamide, ACTH (corticotropin), clonazepam

Walter Fröscher, Volker Faust, Tilman Steinert

Journal of Epileptology, Volume 28 , 35–41

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